Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | MMP12 | P39900 | 2/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27633584 | 0.83 | LMNA (0.49) | LMNAL3MBTL1MAPTALDH1A1KDM4E | |
| SCHEMBL1554320 | 0.82 | KDM4E (0.53) | LMNAL3MBTL1MAPTALDH1A1KDM4E | |
| SCHEMBL21880681 | 0.81 | MTNR1A (0.45) | LMNAL3MBTL1MAPTALDH1A1KDM4E | |
| SCHEMBL9891121 | 0.81 | KDM4E (0.45) | L3MBTL1ALDH1A1KDM4EHSD17B10POLB | |
| SCHEMBL10175060 | 0.80 | PTGS2 (0.51) | L3MBTL1ALDH1A1KDM4EHSD17B10POLB | |
| SCHEMBL1279560 | 0.80 | CHRM2 (0.54) | LMNAL3MBTL1MAPTALDH1A1KDM4E | |
| SCHEMBL3136680 | 0.79 | LMNA (0.48) | LMNAL3MBTL1MAPTALDH1A1KDM4E | |
| SCHEMBL1146046 | 0.79 | CYP2C9 (0.56) | LMNAL3MBTL1MAPTALDH1A1KMT2A | |
| SCHEMBL4309048 | 0.79 | KDM4E (0.48) | LMNAL3MBTL1MAPTALDH1A1KDM4E | |
| SCHEMBL1569021 | 0.78 | LMNA (0.47) | LMNAL3MBTL1MAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994011378-A1 | ARYL THIOPYRANO[2,3,4-c,d]INDOLES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1994-05-26 | — | — | WO | disclosed |
| US-5314900-A | Aryl thiopyrano[2,3,4-C,D]indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1994-05-24 | — | — | US | disclosed |