Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.49 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.49 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.47 |
| ▸ | PDE2A | O00408 | 1/20 | 0.47 |
| ▸ | PDE1A | P54750 | 1/20 | 0.47 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.47 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1063544 | 0.83 | SIRT1 (0.68) | SIRT1SIRT3SIRT5ADORA1ADORA2A | |
| SCHEMBL9430619 | 0.83 | ADORA2A (0.61) | SIRT1SIRT3SIRT5ADORA1PDE4A | |
| SCHEMBL9430131 | 0.82 | ADORA2A (0.56) | SIRT1SIRT3SIRT5ADORA1PDE4A | |
| SCHEMBL9430769 | 0.81 | ADORA2A (0.55) | SIRT1SIRT3SIRT5ADORA1PDE4A | |
| SCHEMBL10856971 | 0.78 | SIRT1 (0.61) | SIRT1SIRT3SIRT5ADORA1PDE4A | |
| SCHEMBL10859893 | 0.78 | SIRT1 (0.61) | SIRT1SIRT3SIRT5ADORA1PDE4A | |
| SCHEMBL18834910 | 0.77 | PDE2A (0.53) | ADORA1PDE2APDE1APDE1BPDE1C | |
| Propanol SCHEMBL9430876 | 0.76 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL11286152 | 0.75 | PDE2A (0.59) | SIRT1SIRT3SIRT5ADORA1PDE2A | |
| SCHEMBL11075794 | 0.75 | SIRT1 (0.54) | SIRT1SIRT3SIRT5ADORA1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5338741-A | Cardiotonic agents | NESTEC S.A. (CH) | 1994-08-16 | — | — | US | disclosed |