Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | TGM2 | P21980 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9433650 | 0.86 | L3MBTL1 (0.40) | POLBALDH1A1MEN1KMT2ATGM2 | |
| SCHEMBL9434756 | 0.82 | CYP3A4 (0.39) | CDC7CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9434449 | 0.81 | RPS6KA3 (0.46) | CDC7 | |
| SCHEMBL9434701 | 0.81 | EGFR (0.40) | SMN1; SMN2ALDH1A1MEN1KMT2ACDC7 | |
| SCHEMBL9433871 | 0.81 | PDE4A (0.37) | PDE4ACDC7MAPT | |
| SCHEMBL9433812 | 0.79 | MAPT (0.43) | PDE4APDE4CPDE4DSMN1; SMN2ALDH1A1 | |
| SCHEMBL9434562 | 0.78 | SLC22A12 (0.47) | TDP1ALDH1A1CHRNB2CHRNA5CHRNA4 | |
| SCHEMBL9434742 | 0.78 | GPBAR1 (0.41) | PDE4ATDP1MEN1KMT2ACYP3A4 | |
| SCHEMBL9433598 | 0.78 | RORC (0.40) | TDP1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL9433930 | 0.77 | GPBAR1 (0.36) | TDP1SMN1; SMN2ALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3002161-A | — | — | None | — | — | JP | disclosed |
| US-5276150-A | Vasodilators, anticoagulants, calcium channel blockers | FUJIREBIO INC. (JP) | 1994-01-04 | — | — | US | disclosed |
| JP-H032161-A | 1,4-DIHYDROPYRIDINE DERIVATIVE | FUJIREBIO INC | 1991-01-08 | — | — | JP | disclosed |
| EP-0400660-A1 | 1,4-dihydropyridine derivatives | FUJIREBIO INC. (JP) | 1990-12-05 | — | — | EP | disclosed |