Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.33 |
| ▸ | GRK2 | P25098 | 1/20 | 0.32 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | CTSA | P10619 | 2/20 | 0.31 |
| ▸ | CDC7 | O00311 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9434756 | 0.86 | CYP3A4 (0.39) | GPBAR1CDC7 | |
| SCHEMBL9434701 | 0.85 | EGFR (0.40) | MAPTCDC7 | |
| SCHEMBL9434449 | 0.85 | RPS6KA3 (0.46) | GPBAR1MMP13FFAR1ROCK2CDC7 | |
| SCHEMBL9433530 | 0.84 | RPS6KA3 (0.35) | GPBAR1MMP13CCNCCDK8MAPT | |
| SCHEMBL9434562 | 0.82 | SLC22A12 (0.47) | PLCG1CCNCCDK8KCNA5CDC7 | |
| SCHEMBL9434742 | 0.82 | GPBAR1 (0.41) | PDE4AGPBAR1ROCK2KCNA5 | |
| SCHEMBL9433930 | 0.81 | GPBAR1 (0.36) | GPBAR1MMP13CCNCCDK8GSK3B | |
| SCHEMBL9433405 | 0.81 | PDE4A (0.43) | PDE4AMAPTCDC7 | |
| SCHEMBL9433586 | 0.78 | MAOA (0.35) | GPBAR1KCNA5 | |
| SCHEMBL9433809 | 0.78 | GPBAR1 (0.36) | GPBAR1MMP13CCNCCDK8ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5276150-A | Vasodilators, anticoagulants, calcium channel blockers | FUJIREBIO INC. (JP) | 1994-01-04 | — | — | US | disclosed |
| EP-0400660-A1 | 1,4-dihydropyridine derivatives | FUJIREBIO INC. (JP) | 1990-12-05 | — | — | EP | disclosed |