Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 7/20 | 0.31 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9434508 | 0.85 | GPBAR1 (0.43) | GPBAR1TACR1 | |
| SCHEMBL9434729 | 0.85 | MAOA (0.36) | MAOAMAOBKCNA5GPBAR1 | |
| SCHEMBL9433625 | 0.84 | KMT2A (0.35) | MAOAMAOBKCNA5GPBAR1 | |
| SCHEMBL9433807 | 0.84 | LIMK1 (0.41) | GPBAR1 | |
| SCHEMBL9434522 | 0.82 | SLC22A12 (0.44) | KCNA5CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL9433534 | 0.81 | GPBAR1 (0.42) | GPBAR1CYP1A2 | |
| SCHEMBL9433598 | 0.80 | RORC (0.40) | CYP1A2CYP2C9 | |
| SCHEMBL9433530 | 0.80 | RPS6KA3 (0.35) | GPBAR1 | |
| SCHEMBL9434595 | 0.79 | MEN1 (0.38) | KCNA5 | |
| SCHEMBL9433711 | 0.79 | SLC22A12 (0.44) | KCNA5CYP1A2CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5276150-A | Vasodilators, anticoagulants, calcium channel blockers | FUJIREBIO INC. (JP) | 1994-01-04 | — | — | US | disclosed |
| EP-0400660-A1 | 1,4-dihydropyridine derivatives | FUJIREBIO INC. (JP) | 1990-12-05 | — | — | EP | disclosed |