Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9434508 | 0.86 | GPBAR1 (0.43) | GPBAR1 | |
| SCHEMBL9433586 | 0.85 | MAOA (0.35) | MAOAMAOBKCNA5GPBAR1 | |
| SCHEMBL9433625 | 0.85 | KMT2A (0.35) | MAOAMAOBHPGDRAB9ACCNC | |
| SCHEMBL9433807 | 0.85 | LIMK1 (0.41) | GSTO1GSK3AGSK3BGPBAR1 | |
| SCHEMBL9434522 | 0.83 | SLC22A12 (0.44) | HPGDKCNA5MAPTSMN1; SMN2CYP3A4 | |
| SCHEMBL9433534 | 0.82 | GPBAR1 (0.42) | HPGDGPBAR1CYP3A4 | |
| SCHEMBL9433598 | 0.81 | RORC (0.40) | RAB9AL3MBTL1KDM4ELMNAMAPT | |
| SCHEMBL9434595 | 0.80 | MEN1 (0.38) | KDM4EKCNA5ROCK2 | |
| SCHEMBL9433711 | 0.80 | SLC22A12 (0.44) | KDM4EKCNA5CDK5LMNACYP3A4 | |
| SCHEMBL9433930 | 0.80 | GPBAR1 (0.36) | HPGDCCNCCDK8KCNA5GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5276150-A | Vasodilators, anticoagulants, calcium channel blockers | FUJIREBIO INC. (JP) | 1994-01-04 | — | — | US | disclosed |
| EP-0400660-A1 | 1,4-dihydropyridine derivatives | FUJIREBIO INC. (JP) | 1990-12-05 | — | — | EP | disclosed |