Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.64 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 8/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.46 |
| ▸ | GCGR | P47871 | 7/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | FRK | P42685 | 2/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.46 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.46 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | TCF4 | P15884 | 1/20 | 0.45 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9347715 | 0.92 | NOX1 (0.60) | ALOX5NOX1TCF4CTNNB1KDM4E | |
| SCHEMBL5435606 | 0.87 | MAPK14 (0.56) | ALOX5MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL11382998 | 0.87 | NOX1 (0.71) | ALOX5NOX1MAPK13MAPK12MAPK11 | |
| SCHEMBL5622957 | 0.84 | ALOX5 (0.87) | ALOX5NOX1MAPK13MAPK12MAPK11 | |
| SCHEMBL5098384 | 0.80 | MAPK14 (0.69) | ALOX5MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL4285506 | 0.80 | MAPK14 (0.69) | ALOX5MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL4551864 | 0.78 | ALOX5 (1.00) | ALOX5NOX1MAPK13MAPK12MAPK11 | |
| SCHEMBL7083925 | 0.77 | PTGS2 (0.73) | ALOX5MAPK11MAPK14CSNK1A1CSNK1D | |
| SCHEMBL9666048 | 0.74 | MAPK13 (0.49) | NOX1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL11714741 | 0.73 | ALOX5 (0.46) | ALOX5NOX1MAPK14CLK4TCF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0231622-B1 | Inhibition of the 5-lipoxygenase pathway | SMITHKLINE BEECHAM CORP (US) | 1994-08-24 | — | — | EP | disclosed |
| US-5134150-A | Administering diaryl-substituted imidazothiazoles; antiarthritic agents | SMITHKLINE BEECHAM CORPORATION (US) | 1992-07-28 | — | — | US | disclosed |
| EP-0231622-A2 | Inhibition of the 5-lipoxygenase pathway | SMITHKLINE BEECHAM CORPORATION (US) | 1987-08-12 | — | — | EP | disclosed |