Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.48 |
| ▸ | CA2 | P00918 | 3/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.37 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.37 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.37 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9135914 | 0.91 | FFAR1 (0.50) | CA1CA2FFAR1KEAP1ALDH1A1 | |
| SCHEMBL5987620 | 0.84 | CA1 (0.50) | CA1CA2FFAR1KEAP1F2RL1 | |
| SCHEMBL3792371 | 0.82 | FFAR1 (0.65) | CA1CA2FFAR1KEAP1FFAR4 | |
| SCHEMBL1154480 | 0.82 | PLAAT3 (0.53) | FFAR1ALDH1A1HDAC1PLAAT3PLAAT5 | |
| SCHEMBL2773933 | 0.82 | ESR1 (0.56) | CA2ALDH1A1HDAC2HDAC8TDP1 | |
| SCHEMBL27473632 | 0.80 | CAPN1 (0.50) | CA1CA2FFAR1KEAP1ALDH1A1 | |
| SCHEMBL30799017 | 0.80 | ALDH1A1 (0.48) | FFAR1KEAP1ALDH1A1HDAC1F2RL1 | |
| SCHEMBL1446802 | 0.80 | FFAR1 (0.55) | FFAR1ALDH1A1PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL594085 | 0.80 | FFAR1 (0.50) | FFAR1HDAC1FFAR4PLAAT3PLAAT5 | |
| SCHEMBL27505250 | 0.80 | TPSAB1 (0.47) | CA1CA2FFAR1KEAP1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526488-B1 | BENZYLPHOSPHONIC ACID TYROSINE KINASE INHIBITORS | PFIZER (US) | 1994-11-30 | — | — | EP | disclosed |
| US-5326905-A | Benzylphosphonic acid tyrosine kinase inhibitors | PFIZER INC. (US) | 1994-07-05 | — | — | US | disclosed |
| EP-0526488-A1 | BENZYLPHOSPHONIC ACID TYROSINE KINASE INHIBITORS. | PFIZER (US) | 1993-02-10 | — | — | EP | disclosed |
| WO-1991015495-A1 | BENZYLPHOSPHONIC ACID TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1991-10-17 | — | — | WO | disclosed |