Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 3/20 | 0.40 |
| ▸ | CNR2 | P34972 | 3/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29064510 | 0.84 | ESR1 (0.43) | SMN1; SMN2CNR1CNR2ESR1ALDH1A1 | |
| SCHEMBL13706022 | 0.83 | CNR1 (0.47) | SMN1; SMN2CNR1CNR2ESR1FBP1 | |
| SCHEMBL73299 | 0.83 | — | — | |
| SCHEMBL28937212 | 0.81 | SMN1; SMN2 (0.40) | SMN1; SMN2CNR1CNR2ESR1FBP1 | |
| Ammonia Solution, Strong SCHEMBL4425485 | 0.81 | SMN1; SMN2 (0.40) | SMN1; SMN2CNR1CNR2ESR1FBP1 | |
| SCHEMBL23573882 | 0.81 | SMN1; SMN2 (0.40) | SMN1; SMN2CNR1CNR2ESR1FBP1 | |
| SCHEMBL355657 | 0.81 | — | — | |
| SCHEMBL9879847 | 0.81 | SMN1; SMN2 (0.40) | SMN1; SMN2CNR1CNR2ESR1FBP1 | |
| SCHEMBL1363215 | 0.81 | SMN1; SMN2 (0.40) | SMN1; SMN2CNR1CNR2ESR1FBP1 | |
| SCHEMBL28239645 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137440-A1 | LYSINE RIBOSWITCHES, STRUCTURE-BASED COMPOUND DESIGN WITH LYSINE RIBOSWITCHES, AND METHODS AND COMPOSITIONS FOR USE OF AND WITH LYSINE RIBOSWITCHES | YALE UNIVERSITY (US) | 2010-06-03 | — | — | US | claimed |
| EP-2061799-A2 | METHODS AND COMPOSITIONS FOR THE USE OF LYSINE RIBOSWITCHES | YALE UNIVERSITY (US) | 2009-05-27 | — | — | EP | claimed |
| WO-2008033866-A2 | METHODS AND COMPOSITIONS FOR THE USE OF LYSINE RIBOSWITCHES | YALE UNIVERSITY (US) | 2008-03-20 | — | — | WO | claimed |
| US-20130012527-A1 | PREQ1 RIBOSWITCHES AND METHODS AND COMPOSITIONS FOR USE OF AND WITH PREQ1 RIBOSWITCHES | YALE UNIVERSITY (US) | 2013-01-10 | — | — | US | disclosed |
| EP-2426219-A1 | Riboswitches and methods and compositions for use of and with riboswitches | Yale University (US) | 2012-03-07 | — | — | EP | disclosed |
| EP-2426218-A1 | Riboswitches and methods and compositions for use of and with riboswitches | Yale University (US) | 2012-03-07 | — | — | EP | disclosed |
| US-20100286082-A1 | RIBOSWITCHES AND METHODS AND COMPOSITIONS FOR USE OF AND WITH RIBOSWITCHES | YALE UNIVERSITY (US) | 2010-11-11 | — | — | US | disclosed |
| US-20100152212-A1 | PREQ1 RIBOSWITCHES AND METHODS AND COMPOSITIONS FOR USE OF AND WITH PREQ1 RIBOSWITCHES | YALE UNIVERSITY (US) | 2010-06-17 | — | — | US | disclosed |
| US-20100137440-A1 | LYSINE RIBOSWITCHES, STRUCTURE-BASED COMPOUND DESIGN WITH LYSINE RIBOSWITCHES, AND METHODS AND COMPOSITIONS FOR USE OF AND WITH LYSINE RIBOSWITCHES | YALE UNIVERSITY (US) | 2010-06-03 | — | — | US | disclosed |
| EP-2164996-A2 | RIBOSWITCHES AND METHODS AND COMPOSITIONS FOR USE OF AND WITH RIBOSWITCHES | YALE UNIVERSITY (US) | 2010-03-24 | — | — | EP | disclosed |
| EP-2139909-A1 | PREQ1 RIBOSWITCHES AND METHODS AND COMPOSITIONS FOR USE OF AND WITH PREQ1 RIBOSWITCHES | Yale University, Inc. (US) | 2010-01-06 | — | — | EP | disclosed |
| EP-2061799-A2 | METHODS AND COMPOSITIONS FOR THE USE OF LYSINE RIBOSWITCHES | YALE UNIVERSITY (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008156987-A9 | RIBOSWITCHES AND METHODS AND COMPOSITIONS FOR USE OF AND WITH RIBOSWITCHES | UNIV YALE (US) | 2009-03-26 | — | — | WO | disclosed |
| WO-2008156987-A2 | RIBOSWITCHES AND METHODS AND COMPOSITIONS FOR USE OF AND WITH RIBOSWITCHES | YALE UNIVERSITY (US) | 2008-12-24 | — | — | WO | disclosed |
| WO-2008116223-A1 | PREQ1 RIBOSWITCHES AND METHODS AND COMPOSITIONS FOR USE OF AND WITH PREQ1 RIBOSWITCHES | YALE UNIVERSITY (US) | 2008-09-25 | — | — | WO | disclosed |
| WO-2008033866-A2 | METHODS AND COMPOSITIONS FOR THE USE OF LYSINE RIBOSWITCHES | YALE UNIVERSITY (US) | 2008-03-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152212-A1 | PREQ1 RIBOSWITCHES AND METHODS AND COMPOSITIONS FOR USE OF AND WITH PREQ1 RIBOSWITCHES | NSUN3, TRDMT1, RPRD2 | SMN1; SMN2 2966/4885CNR1 4406/4885CNR2 4736/4885 |
| US-20100137440-A1 | LYSINE RIBOSWITCHES, STRUCTURE-BASED COMPOUND DESIGN WITH LYSINE RIBOSWITCHES, AND METHODS AND COMPOSITIONS FOR USE OF AND WITH LYSINE RIBOSWITCHES | RNGTT, KARS1, EMG1 | SMN1; SMN2 4105/4885CNR1 4205/4885CNR2 4514/4885 |
| US-20100286082-A1 | RIBOSWITCHES AND METHODS AND COMPOSITIONS FOR USE OF AND WITH RIBOSWITCHES | RNGTT, NSUN3, RNASEH1 | SMN1; SMN2 3587/4885CNR1 4441/4885CNR2 4661/4885 |
| US-20130012527-A1 | PREQ1 RIBOSWITCHES AND METHODS AND COMPOSITIONS FOR USE OF AND WITH PREQ1 RIBOSWITCHES | RNASEH1, NSUN3, RNGTT | SMN1; SMN2 3453/4885CNR1 4450/4885CNR2 4768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.