Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PPID | Q08752 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9445980 | 0.81 | HPGD (0.39) | EGFRMAPTPPIDALDH1A1CCNT1 | |
| SCHEMBL9445917 | 0.79 | HDAC1 (0.41) | EGFRPDCD1CD274PPIDALDH1A1 | |
| SCHEMBL702504 | 0.79 | NPSR1 (0.47) | TSHREGFRPOLBMAPTMAPK1 | |
| SCHEMBL9446006 | 0.76 | MAPT (0.39) | TSHREGFRPOLBMAPTMAPK1 | |
| SCHEMBL9446002 | 0.76 | MAPT (0.39) | TSHREGFRPOLBMAPTMAPK1 | |
| SCHEMBL3312130 | 0.75 | ALDH1A1 (0.48) | TSHRPDCD1CD274POLBALDH1A1 | |
| SCHEMBL914622 | 0.74 | ALDH1A1 (0.51) | TSHREGFRPOLBALDH1A1KDM4E | |
| SCHEMBL1279543 | 0.73 | TSHR (0.60) | TSHREGFRKDM4E | |
| SCHEMBL12212067 | 0.73 | NPSR1 (0.42) | TSHREGFRPOLBMAPTMAPK1 | |
| SCHEMBL9448847 | 0.72 | MAPT (0.43) | EGFRPOLBMAPTMAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5179085-A | Cerebrovascular disorders | WARNER-LAMBERT COMPANY (US) | 1993-01-12 | — | — | US | disclosed |