Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MC4R | P32245 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | MC3R | P41968 | 1/20 | 0.44 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.30 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29956058 | 0.82 | HCAR2 (0.52) | ADORA3TSHRMC4RADRA1AMC3R | |
| SCHEMBL3456606 | 0.82 | HCAR2 (0.52) | ADORA3TSHRMC4RADRA1AMC3R | |
| SCHEMBL18104371 | 0.80 | ALDH1A1 (0.44) | HCAR2KMT2AMEN1 | |
| Water SCHEMBL9818035 | 0.80 | HCAR2 (0.50) | ADORA3TSHRMC4RADRA1AMC3R | |
| SCHEMBL24863014 | 0.78 | ADORA3 (0.45) | ADORA3TSHRMC4RADRA1AMC3R | |
| SCHEMBL1134519 | 0.76 | CNR1 (0.41) | HCAR2KMT2AMEN1 | |
| SCHEMBL9422314 | 0.74 | — | — | |
| SCHEMBL3456871 | 0.73 | CYP1A2 (0.46) | TSHRKMT2AMEN1 | |
| SCHEMBL9422315 | 0.71 | CNR2 (0.31) | LMNA | |
| SCHEMBL5883522 | 0.69 | HCAR2 (0.71) | ADORA3TSHRMC4RADRA1AMC3R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-6256320-A | — | — | None | — | — | JP | disclosed |
| CN-101481713-B | Method for producing aldinamide by biological catalysis of 2-cyano pyrazine and bacterial strain thereof | JIANG University OF TECHNOLOGY (CN) | 2011-12-21 | — | — | CN | disclosed |
| US-20110003691-A1 | Substituted Pyrazinylmethyl Sulfonamides For Use As Fungicides | BASF SE (DE) | 2011-01-06 | — | — | US | disclosed |
| EP-2265592-A1 | SUBSTITUTED PYRAZ INYLMETHYL SULFONAMIDES FOR USE AS. FUNGICIDES | BASF SE (DE) | 2010-12-29 | — | — | EP | disclosed |
| US-7842324-B2 | Bis-aromatic amides and their uses as sweet flavor modifiers, tastants, and taste enhancers | SENOMYX, INC. (US) | 2010-11-30 | — | — | US | disclosed |
| WO-2009112523-A1 | SUBSTITUTED PYRAZ INYLMETHYL SULFONAMIDES FOR USE AS. FUNGICIDES | BASF SE (DE) | 2009-09-17 | — | — | WO | disclosed |
| CN-101481713-A | Method for producing aldinamide by biological catalysis of 2-cyano pyrazine and bacterial strain thereof | UNIV ZHEJIANG TECHNOLOGY (CN) | 2009-07-15 | — | — | CN | disclosed |
| EP-1907353-A2 | BIS-AROMATIC AMIDES AND THEIR USES AS SWEET FLAVOR MODIFIERS, TASTANTS AND TASTE ENHANCERS | Senomyx Inc. (US) | 2008-04-09 | — | — | EP | disclosed |
| US-20070003680-A1 | Bis-aromatic amides and their uses as sweet flavor modifiers, tastants, and taste enhancers | SENOMYX, INC. | 2007-01-04 | — | — | US | disclosed |
| WO-2006138512-A2 | BIS-AROMATIC AMIDES AND THEIR USES AS SWEET FLAVOR MODIFIERS, TASTANTS AND TASTE ENHANCERS | SENOMYX, INC. (US) | 2006-12-28 | — | — | WO | disclosed |
| JP-H06256320-A | PYRAZINE 4-OXIDE DERIVATIVE EFFECTIVE FOR MYCOBACTERIUM TUBERCULOSIS | KOEI CHEM CO LTD | 1994-09-13 | — | — | JP | disclosed |
| US-4293552-A | Novel 1-(mono-o-substituted benzoyl)-3-(substituted pyrazinyl) ureas | ELI LILLY AND COMPANY (US) | 1981-10-06 | — | — | US | disclosed |
| US-4160834-A | INSECTICIDES | ELI LILLY AND COMPANY (US) | 1979-07-10 | — | — | US | disclosed |
| US-4083977-A | Novel insecticidal 1-(substituted benzoyl)-3-(substituted pyrazinyl)ureas | ELI LILLY AND COMPANY (US) | 1978-04-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003691-A1 | Substituted Pyrazinylmethyl Sulfonamides For Use As Fungicides | PRXL2A, ARSA, PADI1 | ADORA3 602/4885TSHR 751/4885MC4R 3563/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.