Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 10/20 | 0.42 |
| ▸ | NPC1 | O15118 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15912483 | 0.83 | FLT1 (0.41) | HPGDSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL9449128 | 0.83 | NFE2L2 (0.51) | HPGDSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL9449016 | 0.83 | SMN1; SMN2 (0.53) | HPGDRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL15524099 | 0.80 | ALDH1A1 (0.40) | HPGDRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL9448913 | 0.80 | JAK2 (0.47) | HPGDRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL15999798 | 0.78 | ACHE (0.43) | HPGDRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL28679242 | 0.77 | HTT (0.46) | NPC1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL9449001 | 0.77 | ALDH1A1 (0.44) | RAB9ANPC1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL846890 | 0.76 | HPGD (0.49) | HPGDGABRA1GABRG2GABRB3GABRB2 | |
| SCHEMBL846889 | 0.76 | HPGD (0.49) | HPGDGABRA1GABRG2GABRB3GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0466730-B1 | GEMINAL BISPHOSPHONIC ACIDS AND DERIVATIVES AS ANTI-ARTHRITIC AGENTS | THE UPJOHN COMPANY (US) | 1993-07-21 | — | — | EP | disclosed |
| US-5220021-A | Geminal bisphosphonic acids and derivatives as anti-arthritic agents | THE UPJOHN COMPANY (US) | 1993-06-15 | — | — | US | disclosed |
| WO-1990012017-A1 | GEMINAL BISPHOSPHONIC ACIDS AND DERIVATIVES AS ANTI-ARTHRITIC AGENTS | THE UPJOHN COMPANY (US) | 1990-10-18 | — | — | WO | disclosed |