Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9449019 | 0.83 | HPGD (0.47) | HTTALDH1A1KMT2AMEN1HIF1A | |
| SCHEMBL15524099 | 0.83 | ALDH1A1 (0.40) | NFE2L2HTTALDH1A1KMT2AMEN1 | |
| SCHEMBL9449001 | 0.83 | ALDH1A1 (0.44) | NFE2L2HTTALDH1A1KMT2AMEN1 | |
| SCHEMBL15999798 | 0.80 | ACHE (0.43) | HTTALDH1A1KMT2AMEN1HIF1A | |
| SCHEMBL28679242 | 0.79 | HTT (0.46) | NFE2L2HTTALDH1A1KMT2AMEN1 | |
| SCHEMBL11023700 | 0.79 | NFE2L2 (0.69) | NFE2L2HTTALDH1A1KMT2AMEN1 | |
| SCHEMBL11023706 | 0.79 | NFE2L2 (0.69) | NFE2L2HTTALDH1A1KMT2AMEN1 | |
| SCHEMBL9448877 | 0.78 | GPR52 (0.45) | HTTALDH1A1KMT2AMEN1HIF1A | |
| SCHEMBL29883889 | 0.78 | GPR52 (0.45) | HTTALDH1A1KMT2AMEN1HIF1A | |
| SCHEMBL9449020 | 0.77 | ALDH1A1 (0.67) | HTTALDH1A1KMT2AMEN1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0466730-B1 | GEMINAL BISPHOSPHONIC ACIDS AND DERIVATIVES AS ANTI-ARTHRITIC AGENTS | THE UPJOHN COMPANY (US) | 1993-07-21 | — | — | EP | disclosed |
| US-5220021-A | Geminal bisphosphonic acids and derivatives as anti-arthritic agents | THE UPJOHN COMPANY (US) | 1993-06-15 | — | — | US | disclosed |
| WO-1990012017-A1 | GEMINAL BISPHOSPHONIC ACIDS AND DERIVATIVES AS ANTI-ARTHRITIC AGENTS | THE UPJOHN COMPANY (US) | 1990-10-18 | — | — | WO | disclosed |