Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9449016 | 0.76 | SMN1; SMN2 (0.53) | ALDH1A1KMT2AMEN1HTTHIF1A | |
| SCHEMBL9178892 | 0.76 | MAPK1 (0.39) | ALDH1A1KMT2ACYP3A4MAPK1TSHR | |
| SCHEMBL9449288 | 0.76 | CES2 (0.52) | ALDH1A1KMT2AMEN1HTTHIF1A | |
| SCHEMBL22123248 | 0.75 | USP2 (0.36) | ALDH1A1KMT2AMEN1HTTHIF1A | |
| SCHEMBL15912483 | 0.74 | FLT1 (0.41) | ALDH1A1KMT2AMEN1HTTHIF1A | |
| SCHEMBL9449019 | 0.74 | HPGD (0.47) | ALDH1A1KMT2AMEN1HTTHIF1A | |
| SCHEMBL6787746 | 0.71 | NPSR1 (0.44) | ALDH1A1KMT2AMEN1HTTHIF1A | |
| SCHEMBL10383925 | 0.70 | CYP3A4 (0.34) | CYP3A4MAPK1GPR27 | |
| SCHEMBL9448906 | 0.70 | TSHR (0.52) | ALDH1A1KMT2AMEN1HTTHIF1A | |
| SCHEMBL14000033 | 0.70 | JAK2 (0.47) | ALDH1A1KMT2AMEN1HTTHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0466730-B1 | GEMINAL BISPHOSPHONIC ACIDS AND DERIVATIVES AS ANTI-ARTHRITIC AGENTS | THE UPJOHN COMPANY (US) | 1993-07-21 | — | — | EP | disclosed |
| US-5220021-A | Geminal bisphosphonic acids and derivatives as anti-arthritic agents | THE UPJOHN COMPANY (US) | 1993-06-15 | — | — | US | disclosed |
| WO-1990012017-A1 | GEMINAL BISPHOSPHONIC ACIDS AND DERIVATIVES AS ANTI-ARTHRITIC AGENTS | THE UPJOHN COMPANY (US) | 1990-10-18 | — | — | WO | disclosed |