Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGFBP3 | P17936 | 11/20 | 0.59 |
| ▸ | IGFBP5 | P24593 | 8/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | IGFBP1 | P08833 | 1/20 | 0.36 |
| ▸ | IGFBP2 | P18065 | 1/20 | 0.36 |
| ▸ | IGFBP4 | P22692 | 1/20 | 0.36 |
| ▸ | IGFBP6 | P24592 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9450689 | 0.73 | KDM4E (0.40) | IGFBP3IGFBP5 | |
| SCHEMBL9319269 | 0.71 | IGFBP5 (0.53) | IGFBP3IGFBP5ALOX15IGFBP1IGFBP2 | |
| SCHEMBL11827386 | 0.68 | IGFBP5 (0.47) | IGFBP3IGFBP5ALOX15IGFBP1IGFBP2 | |
| SCHEMBL8311752 | 0.68 | ALDH1A1 (0.35) | IGFBP3IGFBP5IDO1 | |
| SCHEMBL9319128 | 0.68 | IGFBP3 (0.49) | IGFBP3IGFBP5ALOX15IGFBP1IGFBP2 | |
| SCHEMBL10578056 | 0.67 | IDO1 (0.42) | ALOX15IDO1 | |
| SCHEMBL30420748 | 0.67 | ALOX15 (0.63) | IGFBP3IGFBP5ALOX15 | |
| SCHEMBL11823904 | 0.67 | IGFBP5 (0.46) | IGFBP3IGFBP5ALOX15IGFBP1IGFBP2 | |
| SCHEMBL2905794 | 0.65 | IGFBP5 (0.46) | IGFBP3IGFBP5ALOX15 | |
| SCHEMBL19326306 | 0.63 | ALDH1A1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5250691-A | Heteroaryl derivatives of monocyclic beta-lactam antibiotics | E. R. SQUIBB & SONS, INC. (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0531976-A1 | Heteroaryl derivatives of monocyclic beta-lactam antibiotics | E.R. SQUIBB & SONS, INC. (US) | 1993-03-17 | — | — | EP | disclosed |