Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.46 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.45 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.45 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.40 |
| ▸ | HTR2B known ✓ | P41595 | 2/20 | 0.40 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9451611 | 1.00 | ALDH1A1 (0.47) | ALDH1A1LMNAGAAMAPTCYP2D6 | |
| Fumaric Acid SCHEMBL9451496 | 0.91 | ALDH1A1 (0.47) | ALDH1A1LMNAGAAMAPTCYP2D6 | |
| Fumaric Acid SCHEMBL9451498 | 0.91 | ALDH1A1 (0.47) | ALDH1A1LMNAGAAMAPTCYP2D6 | |
| Fumaric Acid SCHEMBL9451624 | 0.89 | ALDH1A1 (0.46) | ALDH1A1LMNAGAAMAPTCYP2D6 | |
| Fumaric Acid SCHEMBL9451628 | 0.89 | ALDH1A1 (0.46) | ALDH1A1LMNAGAAMAPTCYP2D6 | |
| SCHEMBL9451676 | 0.84 | USP2 (0.52) | ALDH1A1LMNAMAPTCYP2D6CHRM1 | |
| SCHEMBL9451538 | 0.82 | MAPT (0.48) | ALDH1A1LMNAGAAMAPTCYP2D6 | |
| SCHEMBL9451652 | 0.81 | MCHR1 (0.48) | ALDH1A1LMNAMAPTCYP2D6CHRM1 | |
| Fumaric Acid SCHEMBL9451677 | 0.81 | SIGMAR1 (0.52) | ALDH1A1MAPTMCHR1OPRM1HTR2A | |
| Fumaric Acid SCHEMBL9451679 | 0.81 | SIGMAR1 (0.52) | ALDH1A1MAPTMCHR1OPRM1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5260318-A | Phenylpiperidylamines and drugs containing them | BASF AKTIENGESELLSCHAFT (DE) | 1993-11-09 | — | — | US | disclosed |