Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9309032 | 0.75 | KDM4E (0.41) | POLBKMT2AMEN1NPC1RAB9A | |
| SCHEMBL9453103 | 0.74 | POLB (0.42) | POLBKMT2AMEN1NPC1RAB9A | |
| SCHEMBL9453113 | 0.72 | HPGD (0.47) | POLBKMT2AMEN1NPC1RAB9A | |
| Bromide SCHEMBL9453097 | 0.69 | MAPT (0.36) | POLBKMT2AMEN1NPC1RAB9A | |
| Bromide SCHEMBL9308701 | 0.65 | GABRB3 (0.38) | ALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL10675913 | 0.62 | ALDH1A1 (0.49) | POLBKMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL9310026 | 0.62 | ALDH1A1 (0.47) | POLBKMT2AMEN1ALDH1A1MAPT | |
| Bromide SCHEMBL9309040 | 0.60 | GAA (0.42) | KMT2AMEN1RAB9AALDH1A1MAPT | |
| SCHEMBL4536959 | 0.59 | POLB (0.55) | POLBKMT2AMEN1NPC1RAB9A | |
| SCHEMBL720136 | 0.59 | ALDH1A1 (0.59) | POLBKMT2AMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5250504-A | Pre- and postemergence | FMC CORPORATION (US) | 1993-10-05 | — | — | US | disclosed |
| US-5198014-A | Herbicidal beta-pyrazolylacrylic acid compound | FMC CORPORATION (US) | 1993-03-30 | — | — | US | disclosed |