Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 11/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 10/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 10/20 | 0.59 |
| ▸ | OPRD1 | P41143 | 9/20 | 0.59 |
| ▸ | DRD4 | P21917 | 3/20 | 0.56 |
| ▸ | DRD2 | P14416 | 3/20 | 0.56 |
| ▸ | DRD3 | P35462 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.56 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9455848 | 0.87 | OPRM1 (0.54) | OPRL1OPRM1OPRK1OPRD1DRD4 | |
| SCHEMBL9455016 | 0.80 | OPRM1 (0.75) | OPRL1OPRM1OPRK1OPRD1DRD4 | |
| SCHEMBL9677855 | 0.76 | OPRM1 (0.67) | OPRL1OPRM1OPRK1OPRD1DRD4 | |
| SCHEMBL9455222 | 0.76 | OPRM1 (0.68) | OPRL1OPRM1OPRK1OPRD1DRD4 | |
| SCHEMBL9455265 | 0.75 | DRD2 (0.61) | OPRL1OPRM1OPRK1OPRD1DRD4 | |
| SCHEMBL8095160 | 0.74 | OPRM1 (1.00) | OPRL1OPRM1OPRK1OPRD1DRD4 | |
| SCHEMBL9455045 | 0.74 | DRD2 (0.60) | OPRL1OPRM1OPRK1OPRD1DRD4 | |
| SCHEMBL9455308 | 0.73 | SIGMAR1 (0.45) | OPRL1OPRM1OPRK1OPRD1DRD4 | |
| SCHEMBL9912156 | 0.73 | OPRL1 (0.74) | OPRL1OPRM1OPRK1OPRD1DRD4 | |
| SCHEMBL6402803 | 0.73 | OPRM1 (0.74) | OPRL1OPRM1OPRK1OPRD1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0359790-B1 | 1,4-BENZOXAZINE AND 1,4-BENZOTHIAZINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | ERBA CARLO SPA (IT) | 1993-11-03 | — | — | EP | disclosed |
| US-5229383-A | Treating psychotic disorders | FARMITALIA CARLO ERBA S.R.L. (IT) | 1993-07-20 | — | — | US | disclosed |
| US-5084454-A | Tranquilizers and antinausea drugs | FARMITALIA CARLO ERBA S.R.L. (IT) | 1992-01-28 | — | — | US | disclosed |
| EP-0359790-A1 | 1,4-BENZOXAZINE AND 1,4-BENZOTHIAZINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION. | ERBA CARLO SPA (IT) | 1990-03-28 | — | — | EP | disclosed |
| WO-1989007596-A1 | NEW 1,4-BENZOXAZINE AND 1,4-BENZOTHIAZINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-08-24 | — | — | WO | disclosed |