Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ERN1 | O75460 | 1/20 | 0.45 |
| ▸ | ESRRA | P11474 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18957656 | 0.84 | LMNA (0.46) | LMNAKMT2AGAAERN1ALDH1A1 | |
| SCHEMBL6825691 | 0.79 | MAOB (0.52) | KMT2AERN1L3MBTL1NPC1RAB9A | |
| SCHEMBL9114889 | 0.78 | LMNA (0.50) | LMNAKMT2AGAAERN1ALDH1A1 | |
| SCHEMBL11070371 | 0.76 | LTA4H (0.45) | LMNAKMT2AGAAESRRAALDH1A1 | |
| SCHEMBL1849155 | 0.76 | LMNA (0.67) | LMNAKMT2AGAAERN1ALDH1A1 | |
| SCHEMBL8550194 | 0.75 | AR (0.44) | LMNAKMT2AGAAERN1ALDH1A1 | |
| SCHEMBL28451899 | 0.75 | ALDH1A1 (0.69) | LMNAKMT2AGAAERN1ALDH1A1 | |
| SCHEMBL23709919 | 0.75 | LMNA (0.50) | LMNAKMT2AGAAERN1ALDH1A1 | |
| SCHEMBL1134249 | 0.75 | LMNA (0.50) | LMNAKMT2AGAAERN1ALDH1A1 | |
| SCHEMBL14428178 | 0.75 | KMT2A (0.50) | LMNAKMT2AGAAERN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5246960-A | Used to treat obesity, hyperlipaemia, atherosclerosis and arteriosclerosis | HOFFMANN-LA ROCHE INC. (US) | 1993-09-21 | — | — | US | disclosed |
| US-5175186-A | Inhibits pancreas lepase and useful agent in treatment of obesity, hyperlipemia, atherosclerosis and arteriosclerosis | HOFFMANN-LA ROCHE INC. (US) | 1992-12-29 | — | — | US | disclosed |
| US-4931463-A | PANCREAS LIPASE INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1990-06-05 | — | — | US | disclosed |