Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.43 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.41 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9465134 | 1.00 | PTGS2 (0.52) | PTGS2ALDH1A1LMNAHDAC1HDAC8 | |
| SCHEMBL29260522 | 0.94 | PTGS2 (0.55) | PTGS2ALDH1A1LMNACYP1A2MAPT | |
| SCHEMBL10384261 | 0.87 | ALDH1A1 (0.57) | PTGS2ALDH1A1HDAC1HDAC8MAPT | |
| SCHEMBL25170023 | 0.87 | ALDH1A1 (0.49) | ALDH1A1LMNAHDAC1HDAC8CYP1A2 | |
| SCHEMBL25456659 | 0.87 | ALDH1A1 (0.49) | ALDH1A1LMNAHDAC1HDAC8CYP1A2 | |
| SCHEMBL19872975 | 0.86 | ALDH1A1 (0.47) | ALDH1A1LMNAHDAC1HDAC8CYP1A2 | |
| SCHEMBL17490828 | 0.85 | HDAC1 (0.52) | ALDH1A1LMNAHDAC1HDAC8EPHX2 | |
| SCHEMBL22146948 | 0.85 | HDAC1 (0.52) | ALDH1A1LMNAHDAC1HDAC8EPHX2 | |
| SCHEMBL6517314 | 0.83 | ALDH1A1 (0.48) | ALDH1A1LMNAHDAC1HDAC8EPHX2 | |
| SCHEMBL9464294 | 0.82 | TBXAS1 (0.55) | PTGS2ALDH1A1LMNAHDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5242945-A | Antiinflammatory | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-09-07 | — | — | US | disclosed |
| EP-0508690-A1 | Tetronic and thiotetronic acid derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-10-14 | — | — | EP | disclosed |