Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.66 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.66 |
| ▸ | RXRA | P19793 | 1/20 | 0.51 |
| ▸ | RXRB | P28702 | 1/20 | 0.51 |
| ▸ | RXRG | P48443 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | CCKAR | P32238 | 12/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | RPA1 | P27694 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9520508 | 0.81 | ALOX5 (0.83) | PTGS2ALOX5RXRARXRBRXRG | |
| SCHEMBL9465718 | 0.80 | PTGS2 (0.66) | PTGS2ALOX5RXRARXRBRXRG | |
| Tepoxalin SCHEMBL75441 | 0.80 | PTGS2 (1.00) | PTGS2ALOX5RXRARXRBRXRG | |
| SCHEMBL9519062 | 0.80 | PTGS2 (0.81) | PTGS2ALOX5RXRARXRBRXRG | |
| Tepoxalin SCHEMBL9519652 | 0.79 | PTGS2 (0.98) | PTGS2ALOX5RXRARXRBRXRG | |
| SCHEMBL9466052 | 0.78 | PTGS2 (0.72) | PTGS2ALOX5RXRARXRBRXRG | |
| SCHEMBL1984665 | 0.76 | RPA1 (0.68) | PTGS2PTGS1KDM4EALDH1A1MAPT | |
| Formic Acid SCHEMBL9466099 | 0.76 | ALOX5 (0.66) | PTGS2ALOX5RXRARXRBRXRG | |
| SCHEMBL1999172 | 0.76 | PTGS1 (0.56) | PTGS2PTGS1KDM4EALDH1A1MAPT | |
| SCHEMBL6494672 | 0.76 | RPA1 (0.54) | PTGS2PTGS1KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5242940-A | Antiinflammatory agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-09-07 | — | — | US | disclosed |