Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9478335 | 0.86 | RXRA (0.46) | KDM4EALDH1A1RXRARXRBRXRG | |
| SCHEMBL9868786 | 0.76 | TSHR (0.39) | KDM4EALDH1A1KMT2ACNR1CNR2 | |
| SCHEMBL10554610 | 0.74 | KDM4E (0.39) | KDM4EALDH1A1LMNAPOLBRXFP1 | |
| SCHEMBL9468366 | 0.69 | RXRA (0.39) | KDM4EALDH1A1LMNAPOLBRXFP1 | |
| SCHEMBL10551237 | 0.64 | KMO (0.36) | KDM4EALDH1A1LMNAPOLBRXFP1 | |
| SCHEMBL10553556 | 0.63 | KDM4E (0.40) | KDM4EALDH1A1LMNAPOLBRXFP1 | |
| SCHEMBL10554793 | 0.63 | RXRA (0.43) | KDM4EALDH1A1RXRARXRBRXRG | |
| SCHEMBL9870279 | 0.63 | HTT (0.40) | KMT2ANPC1RAB9A | |
| SCHEMBL10852776 | 0.63 | KMT2A (0.49) | KDM4EALDH1A1LMNAPOLBRXFP1 | |
| SCHEMBL29157962 | 0.61 | LRRK2 (0.34) | KDM4EALDH1A1LMNAPOLBRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5219857-A | Method of treating cognitive and related neural behavioral problems | AMERICAN CYANAMID COMPANY (US) | 1993-06-15 | — | — | US | disclosed |
| US-5126340-A | Antidepressants | AMERICAN CYANAMID COMPANY (US) | 1992-06-30 | — | — | US | disclosed |
| US-4963553-A | TREATING COGNITIVE AND NEURAL BEHAVIORAL PROBLEMS IN MAMMALS | AMERICAN CYANAMID CO. (US) | 1990-10-16 | — | — | US | disclosed |