Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | CACNA1F | O60840 | 11/20 | 0.49 |
| ▸ | CACNA1D | Q01668 | 11/20 | 0.49 |
| ▸ | CACNA1S | Q13698 | 11/20 | 0.49 |
| ▸ | CACNA1C | Q13936 | 11/20 | 0.49 |
| ▸ | KIF11 | P52732 | 2/20 | 0.49 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9476049 | 0.88 | CACNA1F (0.64) | ALDH1A1CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL9475589 | 0.85 | KIF11 (0.53) | ALDH1A1CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL9475124 | 0.84 | CACNA1F (0.66) | ALDH1A1CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL9476011 | 0.84 | ALDH1A1 (0.46) | ALDH1A1CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL9475039 | 0.83 | CACNA1F (0.67) | ALDH1A1CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL9475783 | 0.80 | LMNA (0.55) | ALDH1A1CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL9475138 | 0.77 | ALDH1A1 (0.53) | ALDH1A1CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL9475842 | 0.76 | CACNA1F (0.47) | ALDH1A1CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL9475571 | 0.76 | CACNA1F (0.65) | ALDH1A1CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL9475626 | 0.75 | CACNA1F (0.49) | ALDH1A1CACNA1FCACNA1DCACNA1SCACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5202330-A | Hypotensive and cardiovascular agent, reduces blood pressure in mammals | E. R. SQUIBB & SONS, INC. (US) | 1993-04-13 | — | — | US | disclosed |
| EP-0204317-A2 | 2-Thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxylic acid diesters and 3-acyl-5-pyrimidinecarboxylic acids and esters | E.R. Squibb & Sons, Inc. (US) | 1986-12-10 | — | — | EP | disclosed |