Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 6/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | PARP1 | P09874 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9475856 | 0.80 | HPGD (0.59) | TSHRHPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL9476195 | 0.76 | ADORA3 (0.51) | ADORA3ADORA2AADORA2BADORA1TSHR | |
| SCHEMBL9476371 | 0.75 | LMNA (0.53) | ADORA3ADORA2AADORA2BADORA1TSHR | |
| SCHEMBL9476477 | 0.75 | MEN1 (0.62) | TSHRHPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL21127684 | 0.74 | HPRT1 (0.40) | PARP1ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL20224894 | 0.74 | ADORA2A (0.46) | ADORA3ADORA2AADORA2BADORA1HPGD | |
| SCHEMBL9476832 | 0.73 | HSD17B10 (0.57) | ADORA3ADORA2AADORA2BADORA1TSHR | |
| SCHEMBL30931879 | 0.72 | PDE8B (0.53) | ADORA3TSHRHPGDALDH1A1KMT2A | |
| SCHEMBL14094136 | 0.71 | POLB (0.43) | TSHRHPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL23922180 | 0.71 | KDM4A (0.38) | ADORA2AALDH1A1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5204353-A | 3-benzyl-3H-1,2,3-triazolo[4,5-d]pyrimidines, compositions thereof, and method of treating epilepsy therewith | CIBA-GEIGY CORPORATION (US) | 1993-04-20 | — | — | US | disclosed |
| EP-0288431-B1 | 3H-1,2,3-triazolo[4,5-d]pyrimidines | CIBA-GEIGY AG (CH) | 1992-08-19 | — | — | EP | disclosed |
| EP-0288431-A1 | 3H-1,2,3-triazolo[4,5-d]pyrimidines | CIBA-GEIGY AG (CH) | 1988-10-26 | — | — | EP | disclosed |