Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | P4HB | P07237 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9478271 | 1.00 | THRB (0.47) | THRBL3MBTL1MAOBGLO1LMNA | |
| SCHEMBL10747237 | 1.00 | THRB (0.47) | THRBL3MBTL1MAOBGLO1LMNA | |
| SCHEMBL11865025 | 0.92 | GLO1 (0.53) | THRBL3MBTL1MAOBGLO1LMNA | |
| SCHEMBL5381429 | 0.91 | MAOB (0.51) | MAOBLMNAMAPTNFE2L2MEN1 | |
| SCHEMBL8042956 | 0.84 | AKR1C3 (0.58) | THRBL3MBTL1MAOBLMNAMAPT | |
| SCHEMBL5004361 | 0.84 | AKR1C3 (0.58) | THRBL3MBTL1MAOBLMNAMAPT | |
| SCHEMBL6959846 | 0.84 | GAA (0.47) | THRBL3MBTL1MAOBGLO1LMNA | |
| SCHEMBL6959838 | 0.84 | GAA (0.47) | THRBL3MBTL1MAOBGLO1LMNA | |
| SCHEMBL7273073 | 0.82 | P4HB (0.43) | THRBL3MBTL1MAOBLMNAMAPT | |
| SCHEMBL15026404 | 0.81 | GLO1 (0.61) | GLO1LMNAMAPTHPGDNFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5202330-A | Hypotensive and cardiovascular agent, reduces blood pressure in mammals | E. R. SQUIBB & SONS, INC. (US) | 1993-04-13 | — | — | US | disclosed |
| EP-0204317-A2 | 2-Thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxylic acid diesters and 3-acyl-5-pyrimidinecarboxylic acids and esters | E.R. Squibb & Sons, Inc. (US) | 1986-12-10 | — | — | EP | disclosed |