Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HB | P07237 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | FBP1 | P09467 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5381429 | 0.84 | MAOB (0.51) | P4HBMAOBFBP1MEN1KMT2A | |
| SCHEMBL9478264 | 0.82 | THRB (0.47) | P4HBMAOBFBP1MEN1KMT2A | |
| SCHEMBL9478271 | 0.82 | THRB (0.47) | P4HBMAOBFBP1MEN1KMT2A | |
| SCHEMBL10747237 | 0.82 | THRB (0.47) | P4HBMAOBFBP1MEN1KMT2A | |
| SCHEMBL7273129 | 0.80 | MEN1 (0.54) | MEN1KMT2ALMNAMAPTCYP3A4 | |
| SCHEMBL5094449 | 0.78 | EPHX2 (0.55) | P4HBMAOBALDH1A1POLBMEN1 | |
| SCHEMBL5094454 | 0.78 | EPHX2 (0.55) | P4HBMAOBALDH1A1POLBMEN1 | |
| SCHEMBL7271189 | 0.77 | ALDH1A1 (0.56) | MAOBALDH1A1FBP1MEN1KMT2A | |
| SCHEMBL11865025 | 0.77 | GLO1 (0.53) | P4HBMAOBFBP1MEN1KMT2A | |
| SCHEMBL18227995 | 0.77 | MEN1 (0.60) | ALDH1A1POLBMEN1KMT2ANFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0114273-B1 | NEW PHARMACOLOGICALLY ACTIVE PYRAZOLOPYRIDINES | GRUPPO LEPETIT S.p.A. (IT) | 1991-11-06 | — | — | EP | disclosed |
| US-4954508-A | HYPOTENSIVE | GRUPPO LEPETIT S.P.A. (IT) | 1990-09-04 | — | — | US | disclosed |
| EP-0114273-A1 | New pharmacologically active pyrazolopyridines | GRUPPO LEPETIT S.p.A. (IT) | 1984-08-01 | — | — | EP | disclosed |