SCHEMBL9484240

SCHEMBL9484240

O=Cc1cccc2ccc(CCCCCc3ccccc3)cc12

nearest known ligand 0.48

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.48
CYP2D6 P10635 1/20 0.48
CYP2C19 P33261 1/20 0.48
CDK1 P06493 1/20 0.46
IGF1R P08069 1/20 0.41
ALOX15 P16050 1/20 0.41
SIGMAR1 Q99720 6/20 0.41
HDAC1 Q13547 2/20 0.40
HDAC8 Q9BY41 1/20 0.40
MAPT P10636 1/20 0.39
RXFP1 Q9HBX9 1/20 0.39
MAOB P27338 3/20 0.39
DAGLA Q9Y4D2 1/20 0.38
MAOA P21397 1/20 0.38
GPR84 Q9NQS5 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9484152 0.87 LPL (0.46) CYP1A2CYP2D6CYP2C19CDK1
SCHEMBL9484216 0.78 GRM5 (0.42) CYP1A2CYP2D6CYP2C19MAPT
SCHEMBL9142138 0.76 SIGMAR1 (0.50) CYP2D6CDK1SIGMAR1HDAC1MAPT
SCHEMBL9491986 0.76 BID (0.47) CDK1SIGMAR1MAPTRXFP1MAOA
SCHEMBL9483829 0.75 CYP1A2 (0.52) CYP1A2CYP2D6CYP2C19IGF1RALOX15
SCHEMBL9559961 0.73 MAOA (0.51) CDK1IGF1RALOX15SIGMAR1MAPT
SCHEMBL9480031 0.73 MAOA (0.51) CDK1IGF1RALOX15SIGMAR1MAPT
SCHEMBL7091261 0.73 SIGMAR1 (0.50) CDK1SIGMAR1MAPTRXFP1MAOB
SCHEMBL4483973 0.72 ALOX5 (0.59) CDK1MAPTMAOBMAOA
SCHEMBL9485226 0.72 MAPT (0.51) CYP1A2CYP2D6CYP2C19SIGMAR1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0527175-A4 3-NAPHTHYL-3-CARBOXYALKYLTHIO OR OXY SUBSTITUTED ALKANOIC ACID LEUKOTRIENE ANTAGONISTS 1993-05-05 EP disclosed
EP-0527175-A1 3-NAPHTHYL-3-CARBOXYALKYLTHIO OR OXY SUBSTITUTED ALKANOIC ACID LEUKOTRIENE ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1993-02-17 EP disclosed
WO-1991017149-A1 3-NAPHTHYL-3-CARBOXYALKYLTHIO OR OXY SUBSTITUTED ALKANOIC ACID LEUKOTRIENE ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1991-11-14 WO disclosed