Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8684069 | 0.80 | RAB9A (0.46) | MAPK1HCRTR1KDM4EALDH1A1MEN1 | |
| SCHEMBL9485199 | 0.76 | HCRTR1 (0.50) | MAPK1PLK4DAPK3DYRK3JAK2 | |
| SCHEMBL9485928 | 0.75 | HCRTR1 (0.52) | MAPK1PLK4DAPK3DYRK3JAK2 | |
| SCHEMBL9485102 | 0.74 | HCRTR1 (0.44) | MAPK1HCRTR1KDM4EALDH1A1MEN1 | |
| SCHEMBL8682497 | 0.74 | KDM4E (0.39) | MAPK1HCRTR1KDM4EALDH1A1MEN1 | |
| Oxalic Acid SCHEMBL9484406 | 0.73 | HCRTR1 (0.49) | MAPK1PLK4DAPK3DYRK3JAK2 | |
| SCHEMBL8682632 | 0.70 | ALDH1A1 (0.56) | MAPK1HCRTR1KDM4EALDH1A1MEN1 | |
| SCHEMBL4901043 | 0.69 | MEN1 (0.57) | MAPK1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL11749690 | 0.69 | HCRTR1 (0.58) | MAPK1PLK4DAPK3DYRK3JAK2 | |
| SCHEMBL17514133 | 0.68 | HCRTR1 (0.57) | MAPK1PLK4DAPK3DYRK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760028-A | TREATING CANCER METASTASIS, DIABETIC RETINOPATHY, NEOVASCULAR GLAUCOMA, THROMBOSIS, RESTENOSIS, OSTEOPOROSIS, MACULAR DEGENERATION | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-06-02 | — | — | US | disclosed |