Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.66 |
| ▸ | MAPT | P10636 | 6/20 | 0.66 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.66 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.66 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11534549 | 0.79 | KDM4E (1.00) | KDM4EALDH1A1MAPTLIMK1MAPK14 | |
| SCHEMBL948580 | 0.75 | KDM4E (0.77) | KDM4EALDH1A1MAPTLIMK1MAPK14 | |
| SCHEMBL731202 | 0.72 | KDM4E (0.62) | KDM4EALDH1A1MAPTLIMK1MAPK14 | |
| SCHEMBL30498955 | 0.71 | KDM4E (0.47) | KDM4EALDH1A1MAPTLIMK1MAPK14 | |
| SCHEMBL12920662 | 0.71 | CYP2E1 (0.36) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL13266511 | 0.69 | KDM4E (0.57) | KDM4EALDH1A1MAPTLIMK1MAPK14 | |
| SCHEMBL30980040 | 0.69 | ALDH1A1 (0.39) | KDM4EALDH1A1MAPTLIMK1MAPK14 | |
| SCHEMBL2363783 | 0.69 | KDM4E (0.57) | KDM4EALDH1A1MAPTLIMK1MAPK14 | |
| SCHEMBL14985188 | 0.69 | LIMK1 (0.49) | KDM4EALDH1A1MAPTLIMK1MAPK14 | |
| SCHEMBL12386776 | 0.69 | KDM4E (0.49) | KDM4EALDH1A1MAPTLIMK1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11261185-B2 | Bicyclic heterocyclic derivatives | MERCK PATENT GMBH (DE) | 2022-03-01 | — | — | US | disclosed |
| US-20210002278-A1 | BICYCLIC HETEROCYCLIC DERIVATIVES | MERCK PATENT GMBH (DE) | 2021-01-07 | — | — | US | disclosed |
| US-20210002278-A1 | BICYCLIC HETEROCYCLIC DERIVATIVES | MERCK PATENT GMBH (DE) | 2021-01-07 | — | — | US | disclosed |
| US-10829489-B2 | Bicyclic heterocyclic derivatives | MERCK PATENT GMBH (DE) | 2020-11-10 | — | — | US | disclosed |
| US-10829489-B2 | Bicyclic heterocyclic derivatives | MERCK PATENT GMBH (DE) | 2020-11-10 | — | — | US | disclosed |
| US-20200062756-A1 | BICYCLIC HETEROCYCLIC DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-02-27 | — | — | US | disclosed |
| US-20200062756-A1 | BICYCLIC HETEROCYCLIC DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-02-27 | — | — | US | disclosed |
| EP-3328857-B1 | BICYCLIC HETEROCYCLIC DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-08-14 | — | — | EP | disclosed |
| EP-3328857-B1 | BICYCLIC HETEROCYCLIC DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-08-14 | — | — | EP | disclosed |
| US-20190010151-A1 | BICYCLIC HETEROCYCLIC DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-01-10 | — | — | US | disclosed |
| EP-2303876-B1 | DIKETO AZOLOPIPERIDINES AND AZOLOPIPERAZINES AS ANTI-HIV AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2014-03-19 | — | — | EP | disclosed |
| US-8124615-B2 | Diketo substituted pyrrolo[2,3-C]pyridines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-02-28 | — | — | US | disclosed |
| US-8124615-B2 | Diketo substituted pyrrolo[2,3-C]pyridines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-02-28 | — | — | US | disclosed |
| US-20110212971-A1 | DIKETO FUSED AZOLOPIPERIDINES AND AZOLOPIPERAZINES AS ANTI-HIV AGENTS | BRISTOL-MYERS SQUIBB COMPANY | 2011-09-01 | — | — | US | disclosed |
| US-20110212971-A1 | DIKETO FUSED AZOLOPIPERIDINES AND AZOLOPIPERAZINES AS ANTI-HIV AGENTS | BRISTOL-MYERS SQUIBB COMPANY | 2011-09-01 | — | — | US | disclosed |
| US-7960406-B2 | Diketo substituted pyrrolo[2,3-c] pyridines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-06-14 | — | — | US | disclosed |
| US-7960406-B2 | Diketo substituted pyrrolo[2,3-c] pyridines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-06-14 | — | — | US | disclosed |
| US-20100009993-A1 | Diketo Fused Azolopiperidines and Azolopiperazines as Anti-HIV Agents | BRISTOL-MYERS SQUIBB COMPANY | 2010-01-14 | — | — | US | disclosed |
| US-20100009993-A1 | Diketo Fused Azolopiperidines and Azolopiperazines as Anti-HIV Agents | BRISTOL-MYERS SQUIBB COMPANY | 2010-01-14 | — | — | US | disclosed |
| WO-2009158394-A1 | DIKETO AZOLOPIPERIDINES AND AZOLOPIPERAZINES AS ANTI-HIV AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210002278-A1 | BICYCLIC HETEROCYCLIC DERIVATIVES | PDK1, PDK2, PDK3 | KDM4E 1395/4885ALDH1A1 177/4885MAPT 3946/4885 |
| US-20200062756-A1 | BICYCLIC HETEROCYCLIC DERIVATIVES | PDK1, PDK2, PDK3 | KDM4E 1395/4885ALDH1A1 177/4885MAPT 3946/4885 |
| US-20110212971-A1 | DIKETO FUSED AZOLOPIPERIDINES AND AZOLOPIPERAZINES AS ANTI-HIV AGENTS | DHFR, DHPS, DCK | KDM4E 355/4885ALDH1A1 2745/4885MAPT 1743/4885 |
| US-10829489-B2 | Bicyclic heterocyclic derivatives | PDK1, PDK2, PDK3 | KDM4E 1395/4885ALDH1A1 177/4885MAPT 3946/4885 |
| US-20100009993-A1 | Diketo Fused Azolopiperidines and Azolopiperazines as Anti-HIV Agents | DHFR, DHPS, DCK | KDM4E 355/4885ALDH1A1 2745/4885MAPT 1743/4885 |
| US-20190010151-A1 | BICYCLIC HETEROCYCLIC DERIVATIVES | PDK1, PDK2, PDK3 | KDM4E 1395/4885ALDH1A1 177/4885MAPT 3946/4885 |
| US-11261185-B2 | Bicyclic heterocyclic derivatives | PDK1, PDK2, PDK3 | KDM4E 1395/4885ALDH1A1 177/4885MAPT 3946/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.