Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | ATM | Q13315 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | THRB | P10828 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.59 |
| ▸ | MDM4 | O15151 | 1/20 | 0.59 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9487591 | 1.00 | POLB (0.66) | POLBATMALDH1A1THRBCYP2C9 | |
| SCHEMBL27761115 | 0.93 | HDAC1 (0.69) | POLBATMALDH1A1THRBCYP2C9 | |
| SCHEMBL10741167 | 0.91 | ALDH1A1 (0.61) | POLBATMALDH1A1THRBCYP2C9 | |
| SCHEMBL27703697 | 0.90 | HDAC1 (0.56) | POLBATMALDH1A1THRBCYP2C9 | |
| SCHEMBL9487303 | 0.89 | TP53 (0.61) | POLBATMALDH1A1GAARAB9A | |
| SCHEMBL9487298 | 0.89 | TP53 (0.61) | POLBATMALDH1A1GAARAB9A | |
| SCHEMBL15290564 | 0.88 | PSMB5 (0.64) | POLBALDH1A1THRBCYP2C9CYP2C19 | |
| SCHEMBL9487603 | 0.88 | POLB (0.67) | POLBATMALDH1A1THRBCYP2C9 | |
| SCHEMBL9487610 | 0.88 | POLB (0.67) | POLBATMALDH1A1THRBCYP2C9 | |
| SCHEMBL13296315 | 0.88 | TACR1 (0.64) | POLBATMALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180045740-A1 | METHOD OF DIAGNOSIS, PROGNOSIS OR TREATMENT OF NEURODEGENERATIVE DISEASES | Sorbonne Université (FR) | 2018-02-15 | — | — | US | disclosed |
| US-20170247324-A1 | ALDEHYDE CAPTURE LIGATION TECHNOLOGY FOR SYNTHESIS OF AMIDE BONDS | UNIV NEW YORK (US) | 2017-08-31 | — | — | US | disclosed |
| US-9593142-B2 | Aldehyde capture ligation technology for synthesis of amide bonds | NEW YORK UNIVERSITY (US) | 2017-03-14 | — | — | US | disclosed |
| US-9243028-B2 | Facile amide formation via S-nitroso thioacid intermediates | WASHINGTON STATE UNIVERSITY (US) | 2016-01-26 | — | — | US | disclosed |
| US-20150232504-A1 | ALDEHYDE CAPTURE LIGATION TECHNOLOGY FOR SYNTHESIS OF AMIDE BONDS | NEW YORK UNIVERSITY (US) | 2015-08-20 | — | — | US | disclosed |
| US-20120190820-A1 | FACILE AMIDE FORMATION VIA S-NITROSO THIOACID INTERMEDIATES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-07-26 | — | — | US | disclosed |
| US-7354919-B2 | Isoxazole compositions useful as inhibitors of ERK | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-08 | — | — | US | disclosed |
| EP-0198397-B1 | METHOD OF PRODUCING L-PHENYLALANINE | KURARAY CO., LTD. (JP) | 1993-01-07 | — | — | EP | disclosed |
| US-4743547-A | PURITY, ENZYME HYDROLYSIS | KURARAY CO., LTD. (JP) | 1988-05-10 | — | — | US | disclosed |
| EP-0198397-A2 | Method of producing L-phenylalanine | KURARAY CO., LTD. (JP) | 1986-10-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170247324-A1 | ALDEHYDE CAPTURE LIGATION TECHNOLOGY FOR SYNTHESIS OF AMIDE BONDS | ALDH3A1, ALDH2, ALDH1A1 | POLB 887/4885ATM 3346/4885ALDH1A1 3/4885 |
| US-20150232504-A1 | ALDEHYDE CAPTURE LIGATION TECHNOLOGY FOR SYNTHESIS OF AMIDE BONDS | ALDH3A1, ALDH2, ALDH1A1 | POLB 887/4885ATM 3346/4885ALDH1A1 3/4885 |
| US-20180045740-A1 | METHOD OF DIAGNOSIS, PROGNOSIS OR TREATMENT OF NEURODEGENERATIVE DISEASES | MAPT, PSEN2, PSEN1 | POLB 680/4885ATM 1914/4885ALDH1A1 4001/4885 |
| US-20120190820-A1 | FACILE AMIDE FORMATION VIA S-NITROSO THIOACID INTERMEDIATES | NAAA, TST, ASNS | POLB 3466/4885ATM 2526/4885ALDH1A1 3056/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.