SCHEMBL9488176

SCHEMBL9488176

Cc1cc(C)c(C)c(Sc2c(C)c(C)cc(C)c2C)c1

nearest known ligand 0.32

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
RAPGEF4 Q8WZA2 1/20 0.32
MEN1 O00255 1/20 0.31
LMNA P02545 1/20 0.31
TP53 P04637 1/20 0.31
GAA P10253 1/20 0.31
MAPT P10636 1/20 0.31
HPGD P15428 1/20 0.31
ALOX15 P16050 1/20 0.31
ALOX12 P18054 1/20 0.31
KMT2A Q03164 1/20 0.31
HSD17B10 Q99714 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9488033 0.85 MAPT (0.41) RAPGEF4MEN1LMNATP53GAA
SCHEMBL9486776 0.85 MEN1 (0.32) RAPGEF4MEN1LMNATP53GAA
SCHEMBL13386073 0.81 AR (0.35) RAPGEF4MEN1LMNAGAAMAPT
SCHEMBL9487758 0.81 HTR1A (0.40) RAPGEF4MEN1LMNATP53GAA
SCHEMBL9487337 0.77 TUBB4A (0.38) RAPGEF4MEN1LMNATP53GAA
SCHEMBL9486176 0.77 CYP3A4 (0.32)
SCHEMBL9191936 0.75 RAPGEF4 (0.38) RAPGEF4MEN1LMNATP53GAA
SCHEMBL22618598 0.75 RAPGEF4 (0.38) RAPGEF4MEN1LMNATP53GAA
SCHEMBL9488729 0.74 MAPT (0.47) RAPGEF4MEN1LMNATP53GAA
SCHEMBL9485979 0.72 HTR1A (0.44) RAPGEF4MEN1LMNATP53GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5250657-A Process for preparing polyarylene thioether SEISAN KAIHATSU KAGAKU KENKYUSHO (JP) 1993-10-05 US disclosed
EP-0440106-A2 Process for preparing polyarylene thioethers SEISAN KAIHATSU KAGAKU KENKYUSHO (JP) 1991-08-07 EP disclosed