Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLOD2 | O00469 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.53 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.53 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.53 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.53 |
| ▸ | F7 | P08709 | 1/20 | 0.52 |
| ▸ | F3 | P13726 | 1/20 | 0.52 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.52 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.52 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.52 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.52 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.52 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2693872 | 0.84 | PLOD2 (0.61) | PLOD2GAAALDH1A1APPHCAR3 | |
| SCHEMBL22978690 | 0.83 | PLOD2 (0.56) | PLOD2GAAALDH1A1APPHCAR3 | |
| SCHEMBL3982342 | 0.82 | PLOD2 (0.59) | PLOD2GAAALDH1A1APPHCAR3 | |
| SCHEMBL1583591 | 0.79 | ALDH1A1 (0.59) | PLOD2GAAALDH1A1APPHCAR3 | |
| SCHEMBL3983065 | 0.79 | PLOD2 (0.65) | PLOD2GAAALDH1A1APPHCAR3 | |
| SCHEMBL22129599 | 0.79 | ALDH1A1 (0.53) | PLOD2GAAALDH1A1APPHCAR3 | |
| SCHEMBL30633036 | 0.79 | PLOD2 (0.51) | PLOD2GAAALDH1A1APPHCAR3 | |
| SCHEMBL29145564 | 0.79 | PLOD2 (0.51) | PLOD2GAAALDH1A1APPHCAR3 | |
| SCHEMBL15662054 | 0.79 | PLOD2 (0.51) | PLOD2GAAALDH1A1APPHCAR3 | |
| SCHEMBL7075878 | 0.79 | PLOD2 (0.69) | PLOD2GAAALDH1A1APPHCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-1031768-A | — | — | None | — | — | JP | disclosed |
| EP-2668161-B1 | METHOD AND SUBSTANCES FOR PREPARATION OF N-SUBSTITUTED PYRIDINIUM COMPOUNDS | ROCHE DIAGNOSTICS GMBH (DE) | 2014-11-26 | — | — | EP | disclosed |
| US-8754111-B2 | Method and substances for preparation of N-substituted pyridinium compounds | ROCHE DIAGNOSTICS OPERATIONS, INC. (US) | 2014-06-17 | — | — | US | disclosed |
| EP-2668161-A1 | METHOD AND SUBSTANCES FOR PREPARATION OF N-SUBSTITUTED PYRIDINIUM COMPOUNDS | Roche Diagniostics GmbH (DE) | 2013-12-04 | — | — | EP | disclosed |
| US-20130303768-A1 | METHOD AND SUBSTANCES FOR PREPARATION OF N-SUBSTITUTED PYRIDINIUM COMPOUNDS | ROCHE DIAGNOSTICS OPERATIONS, INC. (US) | 2013-11-14 | — | — | US | disclosed |
| WO-2012101095-A1 | METHOD AND SUBSTANCES FOR PREPARATION OF N-SUBSTITUTED PYRIDINIUM COMPOUNDS | ROCHE DIAGNOSTICS GMBH (DE) | 2012-08-02 | — | — | WO | disclosed |
| EP-0302227-B1 | 5-HALO-6-AMINO-NICOTINIC ACID HALIDES, THEIR PREPARATION AND THEIR USE | BAYER AG (DE) | 1993-01-13 | — | — | EP | disclosed |
| EP-0302227-A2 | 5-Halo-6-amino-nicotinic acid halides, their preparation and their use | BAYER AG (DE) | 1989-02-08 | — | — | EP | disclosed |
| EP-0302227-A2 | 5-Halo-6-amino-nicotinic acid halides, their preparation and their use | BAYER AG (DE) | 1989-02-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130303768-A1 | METHOD AND SUBSTANCES FOR PREPARATION OF N-SUBSTITUTED PYRIDINIUM COMPOUNDS | PNMT, HNMT, CHRM5 | PLOD2 1173/4885GAA 2997/4885ALDH1A1 870/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.