Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ACE | P12821 | 3/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL596327 | 0.98 | TSHR (0.58) | TSHRKMT2AHTTL3MBTL1ACE | |
| SCHEMBL11036951 | 0.98 | TSHR (0.58) | TSHRKMT2AHTTL3MBTL1ACE | |
| SCHEMBL948990 | 0.94 | TSHR (0.68) | TSHRKMT2AHTTACEBLM | |
| SCHEMBL21958786 | 0.88 | TSHR (0.49) | TSHRKMT2AHTTL3MBTL1ACE | |
| SCHEMBL6361223 | 0.85 | TSHR (0.50) | TSHRKMT2AHTTACEALDH1A1 | |
| SCHEMBL43400 | 0.85 | — | — | |
| SCHEMBL24263535 | 0.82 | TSHR (0.89) | TSHRKMT2AHTTL3MBTL1BLM | |
| SCHEMBL7770891 | 0.82 | TSHR (0.58) | TSHRKMT2AHTTL3MBTL1BLM | |
| SCHEMBL6502200 | 0.82 | TSHR (0.58) | TSHRKMT2AHTTL3MBTL1BLM | |
| SCHEMBL21389251 | 0.81 | HTT (0.54) | TSHRKMT2AHTTL3MBTL1BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050165053-A1 | Substituted4-aryl-3-(3-aryl-1-oxo-2-propenyl)-2(1h)-quinolinones and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. | 2005-07-28 | — | — | US | claimed |
| EP-4536755-B1 | COMPOSITIONS COMPRISING SURFACE MODIFIED GLOBULAR NANO-PARTICLES | LANDA LABS 2012 LTD (IL) | 2026-02-25 | — | — | EP | disclosed |
| US-20250144039-A1 | COMPOSITIONS COMPRISING SURFACE MODIFIED GLOBULAR NANO-PARTICLES | LANDA LABS (2012) LTD. (IL) | 2025-05-08 | — | — | US | disclosed |
| WO-2025072539-A1 | AMINO ACID COMPOUNDS WITH NITROGEN LINKERS AND USES THEREOF | PLIANT THERAPEUTICS, INC. (US) | 2025-04-03 | — | — | WO | disclosed |
| EP-3645533-B1 | TDO2 AND IDO1 INHIBITORS | GENENTECH INC (US) | 2025-03-26 | — | — | EP | disclosed |
| WO-2024121046-A1 | AMIDE COMPOUNDS AS ACTIVATORS OF THE POTASSIUM CHANNELS KV7.2/KV7.3 USEFUL IN THE TREATMENT OF CNS AND PNS DISORDERS | ANGELINI PHARMA S.P.A. (IT) | 2024-06-13 | — | — | WO | disclosed |
| US-20240132477-A1 | Benzimidazole Derivatives and Their Use As Inhibitors of ITK For The Treatment of Skin Disease | PFIZER INC. (US) | 2024-04-25 | — | — | US | disclosed |
| EP-4340951-A1 | SKIN CARE COMPOSITIONS COMPRISING NANO-ELEMENTS OF COLLAGEN-SYNTHESIS STIMULATING COMPOUNDS AND METHODS OF PREPARING THE SAME | Landa Labs (2012) Ltd. (IL) | 2024-03-27 | — | — | EP | disclosed |
| US-20240082118-A1 | TOPICAL COMPOSITIONS AND METHODS OF PREPARING THE SAME | LANDA LABS (2012) LTD. (IL) | 2024-03-14 | — | — | US | disclosed |
| US-20230357347-A1 | MODULATORS OF G-PROTEIN COUPLED RECEPTORS | CARMOT THERAPEUTICS, INC. | 2023-11-09 | — | — | US | disclosed |
| WO-2002022582-A2 | SOLID SALT FORMS OF N-[2-[4-[2-(1-METHYLETHOXY)PHENYL]-1-PIPERAZINYL]ETHYL]-2-OXO-1-PIPERIDINEACETAMIDE | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2002-03-21 | — | — | WO | disclosed |
| CN-1264300-A | Aryl substituted piperazines useful for treating benign prostatic hypertrophy | ORTHO MCNELL PHARMACEUTICAL IN (US) | 2000-08-23 | — | — | CN | disclosed |
| EP-0755374-B1 | PROCESS FOR PEPTIDE SEGMENT CONDENSATION | MERCK & CO INC (US) | 2000-08-16 | — | — | EP | disclosed |
| US-5773575-A | REACTING A CARBOXYLIC ACID AND AMINE WITH COUPLING AGENT | MERCK & CO., INC. (US) | 1998-06-30 | — | — | US | disclosed |
| US-5665882-A | Pyridyl ethylation of lactams | MERCK & CO., INC. (US) | 1997-09-09 | — | — | US | disclosed |
| US-5559232-A | ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-09-24 | — | — | US | disclosed |
| US-5516759-A | LHRH antagonists having lactam groups at the N-terminus | TAP HOLDINGS INC. (US) | 1996-05-14 | — | — | US | disclosed |
| US-5502165-A | AMIDATION OF CARBOXY COMPOOUND WITH AMINE IN WATER AND SOLVENT | MERCK & CO., INC. (US) | 1996-03-26 | — | — | US | disclosed |
| CN-1107839-A | Carbox amide | HOFFMANN LA ROCHE (CH) | 1995-09-06 | — | — | CN | disclosed |
| US-5444075-A | Penetration enhancers for transdermal delivery of systemic agents | MINASKANIAN GEVORK (US) | 1995-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230357347-A1 | MODULATORS OF G-PROTEIN COUPLED RECEPTORS | GIPR, GLP1R, GCGR | TSHR 140/4885KMT2A 3040/4885HTT 722/4885 |
| US-20240132477-A1 | Benzimidazole Derivatives and Their Use As Inhibitors of ITK For The Treatment of Skin Disease | ITK, BLK, BCKDK | TSHR 3281/4885KMT2A 2121/4885HTT 3979/4885 |
| US-20050165053-A1 | Substituted4-aryl-3-(3-aryl-1-oxo-2-propenyl)-2(1h)-quinolinones and analogs as activators of caspases and inducers of apoptosis and the use thereof | CASP4, CASP3, CASP2 | TSHR 2858/4885KMT2A 3051/4885HTT 2330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.