SCHEMBL9490649

SCHEMBL9490649

NC(=O)N(O)C1CCCc2cc(Oc3ccccc3)ccc21

nearest known ligand 0.86

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
P2RX3 P56373 2/20 0.49
P2RX2 Q9UBL9 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9203514 0.93 ALOX5 (0.46)
SCHEMBL9597113 0.87 PPARD (0.46)
SCHEMBL9488819 0.84 FFAR1 (0.51)
SCHEMBL9489656 0.84 HTR6 (0.47)
SCHEMBL9597770 0.83 ACHE (0.45)
SCHEMBL9206933 0.82 ALOX5 (0.49)
SCHEMBL9596948 0.82 PPARD (0.47)
SCHEMBL9597741 0.82 PPARD (0.47)
SCHEMBL9536933 0.82 ALOX5 (0.41)
SCHEMBL9597053 0.82 ALOX5 (0.54)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0522000-A1 5-LIPOXYGENASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 1993-01-13 EP disclosed
WO-1991014674-A2 5-LIPOXYGENASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 1991-10-03 WO disclosed