Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | RECQL | P46063 | 2/20 | 0.45 |
| ▸ | TTR | P02766 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2,6-Dichlorophenol SCHEMBL65234 | 0.97 | — | — | |
| 2,6-Dichlorophenol SCHEMBL10747747 | 0.93 | TSHR (0.52) | TSHRALDH1A1CYP1A2CYP2A6LMNA | |
| 2,6-Dichlorophenol SCHEMBL30790427 | 0.93 | TSHR (0.52) | TSHRALDH1A1CYP1A2CYP2A6LMNA | |
| 2,6-Dichlorophenol SCHEMBL30257485 | 0.93 | TSHR (0.52) | TSHRALDH1A1CYP1A2CYP2A6LMNA | |
| 2,6-Dichlorophenol SCHEMBL8986495 | 0.90 | TSHR (0.50) | TSHRALDH1A1CYP1A2CYP2A6LMNA | |
| 2,6-Dichlorophenol SCHEMBL28437484 | 0.85 | ALDH1A1 (0.65) | TSHRALDH1A1CYP1A2CYP2A6LMNA | |
| 2,6-Dichlorophenol SCHEMBL5578255 | 0.83 | ALDH1A1 (0.44) | TSHRALDH1A1CYP1A2CYP2A6LMNA | |
| 2,6-Dichlorophenol SCHEMBL28670279 | 0.83 | CA12 (0.58) | TSHRALDH1A1CYP1A2CYP2A6LMNA | |
| 2,6-Dichlorophenol SCHEMBL5010979 | 0.83 | TSHR (0.44) | TSHRALDH1A1CYP1A2CYP2A6LMNA | |
| 2,6-Dichlorophenol SCHEMBL28241861 | 0.83 | ALDH1A1 (0.50) | TSHRALDH1A1CYP1A2CYP2A6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4136075-B1 | PROCESS FOR THE SYNTHESIS OF LOFEXIDINE | MEDICHEM SA (ES) | 2024-06-05 | — | — | EP | disclosed |
| CN-117831658-A | Urine analysis model generation method, urine analysis method and urine analysis system | 杉木(深圳)生物科技有限公司 | 2024-04-05 | — | — | CN | disclosed |
| CN-107986387-B | Ultrasound-assisted selective photocatalysis method and device based on magnetic molecular imprinting | 长安大学 | 2023-09-22 | — | — | CN | disclosed |
| CN-113429308-B | Synthesis process of diclofenac sodium | 安徽普利药业有限公司 | 2023-07-18 | — | — | CN | disclosed |
| CN-113429308-B | Synthesis process of diclofenac sodium | 安徽普利药业有限公司 | 2023-07-18 | — | — | CN | disclosed |
| US-20230123335-A1 | PROCESS FOR THE SYNTHESIS OF LOFEXIDINE | MEDICHEM, S.A. (ES) | 2023-04-20 | — | — | US | disclosed |
| EP-4136075-A1 | PROCESS FOR THE SYNTHESIS OF LOFEXIDINE | Medichem, S.A. (ES) | 2023-02-22 | — | — | EP | disclosed |
| WO-2021209617-A1 | PROCESS FOR THE SYNTHESIS OF LOFEXIDINE | MEDICHEM, S.A. (ES) | 2021-10-21 | — | — | WO | disclosed |
| CN-113429308-A | Process for synthesizing diclofenac sodium | 安徽普利药业有限公司 | 2021-09-24 | — | — | CN | disclosed |
| CN-113429308-A | Process for synthesizing diclofenac sodium | 安徽普利药业有限公司 | 2021-09-24 | — | — | CN | disclosed |
| US-20130087298-A1 | Sensor Wipe For Detecting Surface Conditions | KIMBERLY-CLARK WORLDWIDE, INC. | 2013-04-11 | — | — | US | disclosed |
| EP-2334297-A1 | LOFEXIDINE ENANTIOMERS FOR USE AS A TREATMENT FOR CNS DISEASE AND PATHOLOGIES AND ITS CHIRAL SYNTHESIS | Agean Llc (US) | 2011-06-22 | — | — | EP | disclosed |
| US-20110015246-A2 | LOFEXIDINE ENANTIOMERS FOR USE AS A TREATMENT FOR CNS DISEASE AND PATHOLOGIES AND ITS CHIRAL SYNTHESIS | AGEAN LLC (US) | 2011-01-20 | — | — | US | disclosed |
| WO-2010016844-A1 | LOFEXIDINE ENANTIOMERS FOR USE AS A TREATMENT FOR CNS DISEASE AND PATHOLOGIES AND ITS CHIRAL SYNTHESIS | AGEAN LLC (US) | 2010-02-11 | — | — | WO | disclosed |
| US-20080319041-A1 | Lofexidine enantiomers for use as a treatment for CNS disease and pathologies and its chiral synthesis | AGEAN LLC | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080319041-A1 | Lofexidine enantiomers for use as a treatment for CNS disease and pathologies and its chiral synthesis | CYP2C9, CCR9, PNMT | TSHR 2445/4885ALDH1A1 1426/4885CYP1A2 35/4885 |
| US-20230123335-A1 | PROCESS FOR THE SYNTHESIS OF LOFEXIDINE | LPXN, LOX, LCT | TSHR 1842/4885ALDH1A1 831/4885CYP1A2 172/4885 |
| US-20110015246-A2 | LOFEXIDINE ENANTIOMERS FOR USE AS A TREATMENT FOR CNS DISEASE AND PATHOLOGIES AND ITS CHIRAL SYNTHESIS | CYP2C9, CCR9, PNMT | TSHR 2445/4885ALDH1A1 1426/4885CYP1A2 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.