Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
| ▸ | GUSB | P08236 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.31 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9494117 | 0.92 | KDM4E (0.38) | KDM4ETP53LMNASMN1; SMN2APLNR | |
| SCHEMBL9492707 | 0.90 | APLNR (0.34) | KDM4EAPLNRPARP1RAB9AMAPT | |
| SCHEMBL9491699 | 0.79 | LMNA (0.35) | KDM4ELMNAAPLNRRAB9AMAPT | |
| SCHEMBL8868610 | 0.74 | PARP1 (0.36) | KDM4ETP53LMNASMN1; SMN2PARP1 | |
| SCHEMBL789857 | 0.72 | ABCB11 (0.36) | AGTR1ABCB11EGFRERBB2CYP3A4 | |
| SCHEMBL8587444 | 0.71 | TSHR (0.36) | KDM4ETP53LMNASMN1; SMN2POLB | |
| SCHEMBL8361981 | 0.71 | PTPN11 (0.37) | KDM4ETP53LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL8359536 | 0.70 | KDM4E (0.40) | KDM4ETP53LMNASMN1; SMN2AGTR1 | |
| SCHEMBL9493716 | 0.69 | BRS3 (0.39) | PARP1AGTR1AGTR2 | |
| SCHEMBL9491716 | 0.68 | ELANE (0.35) | SMN1; SMN2APLNRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5243054-A | Hypotensive agents, cardiovascular disorders or nervous system disorders | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-09-07 | — | — | US | disclosed |