Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.43 |
| ▸ | CFTR | P13569 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | ATP4A | P20648 | 1/20 | 0.37 |
| ▸ | ATP4B | P51164 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23950938 | 0.81 | ABCG2 (0.55) | LMNAPOLBCTDSP1L3MBTL1IDO1 | |
| SCHEMBL11613189 | 0.79 | RAB9A (0.61) | LMNAPOLBIDO1ABCG2ABCC1 | |
| SCHEMBL1130756 | 0.78 | IDO1 (0.42) | IDO1ABCG2ABCC1CFTRCYP1A2 | |
| SCHEMBL11787243 | 0.76 | RAB9A (0.61) | LMNAPOLBL3MBTL1IDO1KMT2A | |
| SCHEMBL3877341 | 0.75 | IDO1 (0.52) | LMNAL3MBTL1IDO1NR1I3ALOX5 | |
| SCHEMBL38655973 | 0.75 | IDO1 (0.52) | LMNAL3MBTL1IDO1NR1I3ALOX5 | |
| SCHEMBL25775016 | 0.73 | L3MBTL1 (0.55) | L3MBTL1IDO1ABCG2ABCC1CYP1A2 | |
| SCHEMBL25363001 | 0.73 | LMNA (0.58) | LMNAPOLBCTDSP1L3MBTL1KMT2A | |
| SCHEMBL14321357 | 0.73 | ABCG2 (0.39) | IDO1ABCG2ABCC1CFTRCYP1A2 | |
| Fenclorim SCHEMBL20564320 | 0.72 | LMNA (0.73) | LMNAPOLBCTDSP1L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |