Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | TSHR | P16473 | 5/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10704960 | 0.78 | ERN1 (0.41) | ALDH1A1CYP3A4HPGDERN1KDM4E | |
| SCHEMBL11593707 | 0.74 | TSHR (0.37) | ALDH1A1TSHR | |
| SCHEMBL7308747 | 0.72 | ALDH1A1 (0.43) | ALDH1A1CYP3A4HPGDCA1CA2 | |
| SCHEMBL9712347 | 0.72 | TSHR (0.35) | TSHR | |
| SCHEMBL1312705 | 0.72 | CYP3A4 (0.50) | ALDH1A1TSHRHSD17B10CYP3A4RECQL | |
| SCHEMBL3859125 | 0.71 | ALDH1A1 (0.45) | ALDH1A1TSHRHSD17B10CYP3A4RECQL | |
| SCHEMBL1312947 | 0.71 | CYP3A4 (0.47) | ALDH1A1TSHRHSD17B10CYP3A4RECQL | |
| SCHEMBL952362 | 0.71 | ALDH1A1 (0.45) | ALDH1A1TSHRHSD17B10CYP3A4RECQL | |
| SCHEMBL18245265 | 0.71 | ALDH1A1 (0.45) | ALDH1A1TSHRHSD17B10CYP3A4RECQL | |
| SCHEMBL96213 | 0.71 | CYP1A2 (0.43) | ALDH1A1TSHRMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 405 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE48335-E1 | Polymyxin derivatives as antimicrobial compounds | MONASH UNIVERSITY (AU) | 2020-12-01 | — | — | US | claimed |
| CN-106414480-B | Polymyxin derivatives as antimicrobial compounds | 莫纳什大学 | 2020-08-04 | — | — | CN | claimed |
| EP-2595948-B1 | A METHOD OF PRODUCING INGENOL-3-ANGELATE | LEO LABORATORIES LTD (IE) | 2019-09-04 | — | — | EP | claimed |
| EP-3106477-B1 | (METH)ACRYLIC ACID ESTER COMPOUND AND PRODUCTION METHOD THEREFOR | MITSUBISHI GAS CHEMICAL CO (JP) | 2018-08-29 | — | — | EP | claimed |
| US-20170137469-A1 | POLYMYXIN DERIVATIVES AS ANTIMICROBIAL COMPOUNDS | MONASH UNIVERSITY (AU) | 2017-05-18 | — | — | US | claimed |
| CN-106414480-A | POLYMYXIN DERIVATIVES AS ANTIMICROBIAL COMPOUNDS | 莫纳什大学 | 2017-02-15 | — | — | CN | claimed |
| EP-3126376-A1 | POLYMYXIN DERIVATIVES AS ANTIMICROBIAL COMPOUNDS | Monash University (AU) | 2017-02-08 | — | — | EP | claimed |
| EP-2662376-B1 | PROCESS FOR PREPARING TORISEL | TIANJIN WEIJIE TECHNOLOGY CO LTD (CN) | 2016-11-30 | — | — | EP | claimed |
| US-9234087-B2 | Preparation for initiating radical reactions | UNITED INITIATORS GMBH & CO. KG (DE) | 2016-01-12 | — | — | US | claimed |
| WO-2015149131-A1 | POLYMYXIN DERIVATIVES AS ANTIMICROBIAL COMPOUNDS | MONASH UNIVERSITY (AU) | 2015-10-08 | — | — | WO | claimed |
| EP-1556369-A1 | PYRIDAZINONE-DERIVATIVES AS PDE4 INHIBITORS | ALTANA Pharma AG (DE) | 2005-07-27 | — | — | EP | claimed |
| WO-2005016935-A2 | REGIOSELECTIVE SYNTHESIS OF CCI-779 | WYETH (US) | 2005-02-24 | — | — | WO | claimed |
| EP-1064285-B1 | NOVEL CEPHALOTAXANE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | STRAGEN PHARMA SA (CH) | 2005-02-16 | — | — | EP | claimed |
| US-20050033046-A1 | Regioselective synthesis of CCI-779 | WYETH | 2005-02-10 | — | — | US | claimed |
| WO-2004018451-A1 | PYRIDAZINONE-DERIVATIVES AS PDE4 INHIBITORS | ALTANA PHARMA AG (DE) | 2004-03-04 | — | — | WO | claimed |
| EP-1216251-B1 | REGIOSELECTIVE SYNTHESIS OF RAPAMYCIN DERIVATIVES | WYETH CORP (US) | 2003-02-26 | — | — | EP | claimed |
| EP-1216251-A2 | REGIOSELECTIVE SYNTHESIS OF RAPAMYCIN DERIVATIVES | Wyeth (US) | 2002-06-26 | — | — | EP | claimed |
| US-20010039338-A1 | Regioselective synthesis of rapamycin derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-11-08 | — | — | US | claimed |
| WO-2001023395-A2 | REGIOSELECTIVE SYNTHESIS OF RAPAMYCIN DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-04-05 | — | — | WO | claimed |
| US-4727079-A | Brain-specific dopaminergic activity involving dihydropyridine carboxamides, dihydroquinoline and isoquinoline carboxamides | UNIVERSITY OF FLORIDA (US) | 1988-02-23 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010039338-A1 | Regioselective synthesis of rapamycin derivatives | RICTOR, MTOR, RPTOR | ALDH1A1 4478/4885TSHR 2980/4885HSD17B10 1308/4885 |
| US-20050033046-A1 | Regioselective synthesis of CCI-779 | CCR9, CCR7, CCL11 | ALDH1A1 1415/4885TSHR 3793/4885HSD17B10 1437/4885 |
| US-20170137469-A1 | POLYMYXIN DERIVATIVES AS ANTIMICROBIAL COMPOUNDS | VIP, PEPD, NRDC | ALDH1A1 4861/4885TSHR 4543/4885HSD17B10 4287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.