Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 8/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | PPARA | Q07869 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MDM4 | O15151 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL9499382 | 0.76 | SLC6A4 (0.59) | SLC6A4LMNAMEN1KMT2ANPC1 | |
| Fumaric Acid SCHEMBL9499394 | 0.76 | SLC6A4 (0.59) | SLC6A4LMNAMEN1KMT2ANPC1 | |
| SCHEMBL16347642 | 0.75 | SLC6A9 (0.47) | SLC6A4PPARGPPARALMNAMEN1 | |
| SCHEMBL6491987 | 0.74 | NOS2 (0.61) | SLC6A4MEN1KMT2ACYP2D6CYP2C19 | |
| SCHEMBL5037911 | 0.73 | SLC6A2 (0.36) | SLC6A4LMNAMEN1KMT2ACYP2D6 | |
| SCHEMBL9184202 | 0.71 | SLC6A2 (0.34) | SLC6A4LMNAMEN1KMT2ACYP2D6 | |
| SCHEMBL6502150 | 0.71 | SLC6A4 (0.40) | SLC6A4HCAR2LMNAMEN1KMT2A | |
| SCHEMBL7312423 | 0.69 | SLC6A9 (0.46) | HCAR2PPARGPPARAMEN1KMT2A | |
| SCHEMBL4941291 | 0.69 | SLC6A4 (0.47) | SLC6A4PPARGPPARALMNAKMT2A | |
| SCHEMBL6501564 | 0.69 | NOS2 (0.47) | SLC6A4LMNAMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5238959-A | For inhibiting serotonin uptake, antidepressant, suppression of alcoholism and obesity | ELI LILLY AND COMPANY (US) | 1993-08-24 | — | — | US | disclosed |
| EP-0336753-B1 | IMPROVEMENTS IN OR RELATING TO PROPANAMINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1992-07-08 | — | — | EP | disclosed |
| EP-0336753-A1 | Improvements in or relating to propanamine derivatives | ELI LILLY AND COMPANY (US) | 1989-10-11 | — | — | EP | disclosed |