SCHEMBL9499640

SCHEMBL9499640

C[Si](C)(C)C#Cc1ccccc1S(N)(=O)=O

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 11/20 0.59
CA9 Q16790 10/20 0.59
CA12 O43570 5/20 0.59
ALOX5 P09917 1/20 0.46
CA1 P00915 8/20 0.42
CA6 P23280 3/20 0.42
CA5A P35218 3/20 0.42
CA4 P22748 2/20 0.42
CA7 P43166 2/20 0.42
CA5B Q9Y2D0 2/20 0.42
CYP2C9 P11712 2/20 0.42
CA14 Q9ULX7 1/20 0.42
ALDH1A1 P00352 2/20 0.38
KDM4E B2RXH2 1/20 0.38
MEN1 O00255 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
MAPT P10636 1/20 0.38
HPGD P15428 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31262949 1.00 CA2 (0.59) CA2CA9CA12ALOX5CA1
SCHEMBL9586213 0.79 CA2 (0.65) CA2CA9CA12ALOX5CA1
SCHEMBL4405907 0.77 NSD2 (0.42) CYP2C9ALDH1A1KDM4EMEN1CYP1A2
SCHEMBL3839029 0.76 KDM4E (0.49) CYP2C9ALDH1A1KDM4EMEN1CYP1A2
SCHEMBL9585789 0.75 CA2 (0.59) CA2CA9CA12ALOX5CA1
SCHEMBL9586802 0.75 CA2 (0.59) CA2CA9CA12ALOX5CA1
SCHEMBL9588168 0.74 CA2 (0.57) CA2CA9CA12ALOX5CA1
SCHEMBL18297445 0.73 CA2 (0.40) CA2CA9CA12CA1CA6
SCHEMBL5501971 0.72 CA2 (0.60) CA2CA9CA12ALOX5CA1
SCHEMBL9586207 0.72 CA2 (0.56) CA2CA9CA12ALOX5CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4634155-A1 RBM39 SULFONAMIDE INHIBITORS Recursion Pharmaceuticals, Inc. (US) 2025-10-22 EP disclosed
US-20250248973-A1 CANNABINOID RECEPTOR 1 ANTAGONISTS/INVERSE AGONISTS AND USES THEREOF CORBUS PHARMACEUTICALS, INC. 2025-08-07 US disclosed
EP-4504179-A1 CANNABINOID RECEPTOR 1 ANTAGONISTS/INVERSE AGONISTS AND USES THEREOF Corbus Pharmaceuticals, Inc. (US) 2025-02-12 EP disclosed
WO-2024129634-A1 RBM39 SULFONAMIDE INHIBITORS RECURSION PHARMACEUTICALS, INC. (US) 2024-06-20 WO disclosed
WO-2023196556-A1 CANNABINOID RECEPTOR 1 ANTAGONISTS/INVERSE AGONISTS AND USES THEREOF CORBUS PHARMACEUTICALS, INC. (US) 2023-10-12 WO disclosed
WO-2023196556-A1 CANNABINOID RECEPTOR 1 ANTAGONISTS/INVERSE AGONISTS AND USES THEREOF CORBUS PHARMACEUTICALS, INC. (US) 2023-10-12 WO disclosed
EP-3668856-A1 NOVEL TETRAZOLE COMPOUNDS AND THEIR USE IN THE TREATMENT OF TUBERCULOSIS GlaxoSmithKline Intellectual Property Development Limited (GB) 2020-06-24 EP disclosed
WO-2019034729-A1 NOVEL TETRAZOLE COMPOUNDS AND THEIR USE IN THE TREATMENT OF TUBERCULOSIS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2019-02-21 WO disclosed
EP-3096754-A1 METALLO-BETA-LACTAMASE INHIBITORS Merck Sharp & Dohme Corp. (US) 2016-11-30 EP disclosed
WO-2015112441-A1 METALLO-BETA-LACTAMASE INHIBITORS MERCK SHARP & DOHME CORP. (US) 2015-07-30 WO disclosed
US-5248693-A Antiallergens, antiinflammatory agents CIBA-GEIGY CORPORATION (US) 1993-09-28 US disclosed
EP-0539329-A1 Acetenyl compounds useful as leukotrien antagonists CIBA-GEIGY AG (CH) 1993-04-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250248973-A1 CANNABINOID RECEPTOR 1 ANTAGONISTS/INVERSE AGONISTS AND USES THEREOF CNR1, CNR2, GPR119 CA2 4564/4885CA9 3789/4885CA12 4522/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.