Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | FABP4 | P15090 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17576252 | 0.81 | KDM4E (0.49) | HTR2CCYP2A6HTR6MAPTKDM4E | |
| SCHEMBL9495836 | 0.77 | DAO (0.47) | DAOHTR2CCYP2A6MAPTKDM4E | |
| SCHEMBL28033876 | 0.76 | MTNR1B (0.40) | DAOHTR2CCYP2A6HTR6MAPT | |
| SCHEMBL2800336 | 0.73 | TNFRSF1A (0.43) | HTR2CCYP2A6HTR6MAPTALDH1A1 | |
| SCHEMBL28682498 | 0.73 | HTR2C (0.51) | DAOHTR2CHTR6MAPTKDM4E | |
| SCHEMBL2798034 | 0.72 | CCR2 (0.39) | HTR2CCYP2A6HTR6KDM4ELMNA | |
| SCHEMBL8844829 | 0.71 | KCNA3 (0.46) | HTR2CMAPTALDH1A1LMNAPOLB | |
| SCHEMBL4557712 | 0.68 | CYP19A1 (0.41) | DAOMAPTKDM4EALDH1A1LMNA | |
| SCHEMBL29992724 | 0.68 | HTR6 (0.52) | DAOHTR2CHTR6KDM4EALDH1A1 | |
| SCHEMBL15018734 | 0.68 | HTR6 (0.52) | DAOHTR2CHTR6KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0240859-B1 | LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1993-04-28 | — | — | EP | disclosed |