Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | RCE1 | Q9Y256 | 2/20 | 0.34 |
| ▸ | AKR1A1 | P14550 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.33 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP14 | P50281 | 1/20 | 0.32 |
| ▸ | GHSR | Q92847 | 2/20 | 0.32 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALPL | P05186 | 1/20 | 0.31 |
| ▸ | ALPI | P09923 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL949825 | 1.00 | AR (0.34) | ARALDH1A1AKR1B1GAAMAPT | |
| SCHEMBL950827 | 1.00 | AR (0.34) | ARALDH1A1AKR1B1GAAMAPT | |
| SCHEMBL949680 | 0.88 | AKR1B1 (0.37) | ALDH1A1AKR1B1GAAMAPTRCE1 | |
| SCHEMBL950207 | 0.88 | AKR1B1 (0.37) | ALDH1A1AKR1B1GAAMAPTRCE1 | |
| SCHEMBL953677 | 0.88 | AKR1B1 (0.37) | ALDH1A1AKR1B1GAAMAPTRCE1 | |
| SCHEMBL13781378 | 0.78 | CHRM5 (0.35) | PTGDR2 | |
| SCHEMBL4263796 | 0.74 | ITGA4 (0.43) | ALDH1A1AKR1B1GAAMAPTAKR1A1 | |
| SCHEMBL4168480 | 0.74 | ALDH1A1 (0.36) | ALDH1A1AKR1B1GAAMAPTRCE1 | |
| SCHEMBL4261580 | 0.73 | AKR1B1 (0.44) | ALDH1A1AKR1B1GAAMAPTRCE1 | |
| SCHEMBL953500 | 0.73 | ALDH1A1 (0.60) | ALDH1A1MAPTRCE1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868181-B2 | Compounds | ASTRAZENECA AB (SE) | 2011-01-11 | — | — | US | disclosed |
| US-20090137650-A1 | New Compounds | LEUNG CARMEN | 2009-05-28 | — | — | US | disclosed |
| US-20070185179-A1 | New compounds | ASTRAZENECA AB (SE) | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137650-A1 | New Compounds | CLIC1, AQP1, AVPR2 | AR 3835/4885ALDH1A1 1551/4885AKR1B1 847/4885 |
| US-20070185179-A1 | New compounds | CLIC1, AQP1, AVPR2 | AR 3835/4885ALDH1A1 1551/4885AKR1B1 847/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.