Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 6/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CCKAR | P32238 | 3/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | PYGL | P06737 | 1/20 | 0.42 |
| ▸ | PYGM | P11217 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9499432 | 0.83 | OPRM1 (0.49) | CCKBROPRK1 | |
| SCHEMBL9499330 | 0.79 | CCKBR (0.58) | CCKBRMEN1KMT2ACCKARDRD2 | |
| SCHEMBL9500427 | 0.77 | CCKBR (1.00) | CCKBRCCKAROPRK1 | |
| SCHEMBL9501463 | 0.75 | LMNA (0.52) | CCKBRKMT2AALDH1A1 | |
| SCHEMBL9683424 | 0.70 | CCKBR (0.38) | CCKBRMEN1KMT2AOPRK1HTR2C | |
| SCHEMBL18767964 | 0.69 | SLC6A2 (0.59) | KDM4EHSD17B10HPGDDRD2DRD3 | |
| SCHEMBL6885051 | 0.68 | KDM4E (0.67) | KDM4EHSD17B10HPGDDRD2DRD3 | |
| SCHEMBL9682641 | 0.68 | CCKBR (0.37) | CCKBRKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL18768421 | 0.67 | KMT2A (0.58) | CCKBRKDM4EHSD17B10HPGDMEN1 | |
| SCHEMBL10659731 | 0.67 | KDM4E (0.38) | CCKBRKDM4EHSD17B10HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0486271-A2 | Cholecystokinin antagonists for treating neurological disorders | MERCK & CO. INC. (US) | 1992-05-20 | — | — | EP | claimed |
| US-4724237-A | GASTROINTESTINAL, CENTRAL NERVOUS, AND APPETITE DISORDERS | MERCK & CO., INC. (US) | 1988-02-09 | — | — | US | claimed |
| US-5206238-A | Cholecystokinin antagonists | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| EP-0486271-A2 | Cholecystokinin antagonists for treating neurological disorders | MERCK & CO. INC. (US) | 1992-05-20 | — | — | EP | disclosed |
| US-4724237-A | GASTROINTESTINAL, CENTRAL NERVOUS, AND APPETITE DISORDERS | MERCK & CO., INC. (US) | 1988-02-09 | — | — | US | disclosed |
| EP-0166356-A2 | 2-Substituted-aminomethyl-1,4-benzodiazepines, process for their preparation and pharmaceutical compositions containing them | MERCK & CO. INC. (US) | 1986-01-02 | — | — | EP | disclosed |