Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 5/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.38 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15668991 | 0.94 | MAPT (0.43) | CHRM1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL15668834 | 0.87 | HSD11B1 (0.45) | MEN1KMT2AALDH1A1MAPTHSD11B1 | |
| SCHEMBL12579033 | 0.80 | MEN1 (0.45) | MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL15669006 | 0.78 | ALDH1A1 (0.40) | GPR84MEN1KMT2APAK1ALDH1A1 | |
| SCHEMBL4822817 | 0.78 | GPR84 (0.45) | CHRM1GPR84CHRM2CHRM3PAK1 | |
| SCHEMBL2749556 | 0.77 | SMN1; SMN2 (0.63) | MEN1KMT2AHAO1ALDH1A1 | |
| SCHEMBL1743341 | 0.76 | SMN1; SMN2 (0.42) | CHRM1GPR84MEN1KMT2APAK1 | |
| SCHEMBL11625750 | 0.76 | ALDH1A1 (0.41) | CHRM1CHRM2CHRM3ALDH1A1 | |
| SCHEMBL9502601 | 0.75 | GPR84 (0.43) | CHRM1GPR84CHRM2CHRM3PAK1 | |
| SCHEMBL2341793 | 0.75 | SMN1; SMN2 (0.65) | MEN1KMT2AALDH1A1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0548291-A1 | PYRIDYLTHIO OR PYRIDYLOXY ALKANOIC ACIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-06-30 | — | — | EP | disclosed |
| WO-1992005156-A1 | PYRIDYLTHIO OR PYRIDYLOXY ALKANOIC ACIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-04-02 | — | — | WO | disclosed |