SCHEMBL1743341

SCHEMBL1743341

CCCCCSc1ncccc1N

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 4/20 0.42
ALDH1A1 P00352 5/20 0.41
KDM4E B2RXH2 3/20 0.41
HPGD P15428 2/20 0.41
CYP1A2 P05177 2/20 0.41
CYP2C9 P11712 2/20 0.41
CYP2C19 P33261 2/20 0.41
CYP3A4 P08684 1/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
MAPT P10636 2/20 0.41
GAA P10253 1/20 0.41
HTT P42858 1/20 0.41
GPR84 Q9NQS5 1/20 0.41
PAK1 Q13153 1/20 0.41
THRB P10828 1/20 0.40
CHRM1 P11229 1/20 0.39
NPSR1 Q6W5P4 1/20 0.38
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15584059 0.95 ALDH1A1 (0.42) SMN1; SMN2ALDH1A1KDM4EHPGDCYP1A2
SCHEMBL4822817 0.81 GPR84 (0.45) ALDH1A1MAPTGPR84PAK1CHRM1
SCHEMBL7502160 0.77 ALDH1A1 (0.49) SMN1; SMN2ALDH1A1KDM4EHPGDCYP2C9
SCHEMBL9501511 0.76 CHRM1 (0.41) ALDH1A1MEN1KMT2AMAPTGPR84
SCHEMBL16334477 0.76 MAPT (0.43) SMN1; SMN2ALDH1A1HPGDCYP1A2CYP2C9
SCHEMBL9502601 0.75 GPR84 (0.43) ALDH1A1MAPTGPR84PAK1CHRM1
SCHEMBL2341793 0.75 SMN1; SMN2 (0.65) SMN1; SMN2ALDH1A1KDM4ECYP2C9MEN1
SCHEMBL1721218 0.75 ALDH1A1 (0.52) SMN1; SMN2ALDH1A1KDM4EHPGDCYP1A2
SCHEMBL3869492 0.74 SMN1; SMN2 (0.49) SMN1; SMN2ALDH1A1HPGDCYP2C9MEN1
SCHEMBL2749556 0.74 SMN1; SMN2 (0.63) SMN1; SMN2ALDH1A1KDM4ECYP2C9MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9518063-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2016-12-13 US claimed
CN-102341401-B New materials with aza-dibenzothiophene or aza-dibenzofuran core for PHOLEDs UNIVERSAL DISPLAY CORP. (US) 2016-02-10 CN claimed
EP-2387576-B1 NEW MATERIALS WITH AZA-DIBENZOTHIOPHENE OR AZA-DIBENZOFURAN CORE FOR PHOLED UNIVERSAL DISPLAY CORP (US) 2016-01-13 EP claimed
US-20150274749-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2015-10-01 US claimed
EP-2387576-A2 NEW MATERIALS WITH AZA-DIBENZOTHIOPHENE OR AZA-DIBENZOFURAN CORE FOR PHOLED Universal Display Corporation (US) 2011-11-23 EP claimed
US-20100187984-A1 MATERIALS WITH AZA-DIBENZOTHIOPHENE OR AZA-DIBENZOFURAN CORE FOR PHOLED UNIVERSAL DISPLAY CORPORATION (US) 2010-07-29 US claimed
WO-2010083359-A2 NEW MATERIALS WITH AZA-DIBENZOTHIOPHENE OR AZA-DIBENZOFURAN CORE FOR PHOLED UNIVERSAL DISPLAY CORPORATION (US) 2010-07-22 WO claimed
CN-106397453-B New materials with aza-dibenzothiophene or aza-dibenzofuran core for PHOLEDs 通用显示公司 2021-06-18 CN disclosed
EP-3689882-A1 NEW MATERIALS WITH AZA-DIBENZOTHIOPHENE OR AZA-DIBENZOFURAN CORE FOR PHOLED Universal Display Corporation (US) 2020-08-05 EP disclosed
EP-3318566-B1 AZADIBENZOFURANS FOR ELECTRONIC APPLICATIONS UDC IRELAND LTD (IE) 2020-06-24 EP disclosed
EP-2703405-B1 NEW MATERIALS WITH AZA-DIBENZOTHIOPHENE OR AZA-DIBENZOFURAN CORE FOR PHOLED UNIVERSAL DISPLAY CORP (US) 2020-04-15 EP disclosed
US-20190131547-A1 AZADIBENZOFURANS FOR ELECTRONIC APPLICATIONS UDC IRELAND LTD (IE) 2019-05-02 US disclosed
US-10249827-B2 Azadibenzofurans for electronic applications UDC IRELAND LIMITED (IE) 2019-04-02 US disclosed
US-8952363-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2015-02-10 US disclosed
WO-2014044722-A1 AZADIBENZOFURANS FOR ELECTRONIC APPLICATIONS BASF SE (DE) 2014-03-27 WO disclosed
EP-2703405-A2 New materials with aza-dibenzothiophene or aza-dibenzofuran core for pholed Universal Display Corporation (US) 2014-03-05 EP disclosed
US-20130060037-A1 MATERIALS WITH AZA-DIBENZOTHIOPHENE OR AZA-DIBENZOFURAN CORE FOR PHOLED UNIVERSAL DISPLAY CORPORATION (US) 2013-03-07 US disclosed
EP-2387576-A2 NEW MATERIALS WITH AZA-DIBENZOTHIOPHENE OR AZA-DIBENZOFURAN CORE FOR PHOLED Universal Display Corporation (US) 2011-11-23 EP disclosed
US-20100187984-A1 MATERIALS WITH AZA-DIBENZOTHIOPHENE OR AZA-DIBENZOFURAN CORE FOR PHOLED UNIVERSAL DISPLAY CORPORATION (US) 2010-07-29 US disclosed
WO-2010083359-A2 NEW MATERIALS WITH AZA-DIBENZOTHIOPHENE OR AZA-DIBENZOFURAN CORE FOR PHOLED UNIVERSAL DISPLAY CORPORATION (US) 2010-07-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150274749-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES DDT, AZI2, EED SMN1; SMN2 2253/4885ALDH1A1 399/4885KDM4E 306/4885
US-20190131547-A1 AZADIBENZOFURANS FOR ELECTRONIC APPLICATIONS AZI2, BRPF1, CCNB1 SMN1; SMN2 3068/4885ALDH1A1 547/4885KDM4E 1361/4885
US-20130060037-A1 MATERIALS WITH AZA-DIBENZOTHIOPHENE OR AZA-DIBENZOFURAN CORE FOR PHOLED DDT, FZD7, BRD7 SMN1; SMN2 3714/4885ALDH1A1 1449/4885KDM4E 832/4885
US-10249827-B2 Azadibenzofurans for electronic applications AZI2, BRPF1, CCNB1 SMN1; SMN2 3068/4885ALDH1A1 547/4885KDM4E 1361/4885
US-20100187984-A1 MATERIALS WITH AZA-DIBENZOTHIOPHENE OR AZA-DIBENZOFURAN CORE FOR PHOLED DDT, FZD7, BRD7 SMN1; SMN2 3714/4885ALDH1A1 1449/4885KDM4E 832/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.