SCHEMBL9502208

SCHEMBL9502208

CC(CCc1ccccc1)NS(=O)(=O)c1ccc(CC2(C)N=c3ccccc3=N2)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.64
CYP1A2 P05177 1/20 0.64
CYP2C9 P11712 1/20 0.64
CYP2C19 P33261 1/20 0.64
POLB P06746 2/20 0.62
L3MBTL1 Q9Y468 1/20 0.49
NR3C1 P04150 2/20 0.48
SMN1; SMN2 Q16637 2/20 0.47
MMP2 P08253 1/20 0.45
MMP7 P09237 1/20 0.45
MMP9 P14780 1/20 0.45
MMP8 P22894 1/20 0.45
MMP13 P45452 1/20 0.45
MMP14 P50281 1/20 0.45
NPSR1 Q6W5P4 1/20 0.41
CA12 O43570 1/20 0.40
CA2 P00918 1/20 0.40
CA9 Q16790 1/20 0.40
HTR7 P34969 1/20 0.39
CACNA1G O43497 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9502025 0.88 ALDH1A1 (0.47) ALDH1A1CYP1A2CYP2C9CYP2C19POLB
SCHEMBL8560865 0.85 SMN1; SMN2 (0.49) ALDH1A1CYP1A2CYP2C9CYP2C19POLB
SCHEMBL9502675 0.82 CA2 (0.51) ALDH1A1CYP1A2CYP2C9CYP2C19POLB
SCHEMBL9299658 0.81 DUT (0.48) ALDH1A1CYP1A2CYP2C9CYP2C19POLB
SCHEMBL9501945 0.80 ALDH1A1 (0.47) ALDH1A1L3MBTL1MMP2MMP9CA2
SCHEMBL4501291 0.79 ALDH1A1 (0.81) ALDH1A1CYP1A2CYP2C9CYP2C19POLB
SCHEMBL13889012 0.78 ALDH1A1 (0.83) ALDH1A1CYP1A2CYP2C9CYP2C19POLB
SCHEMBL8134454 0.77 GAA (0.47) MMP2MMP7MMP9MMP13
SCHEMBL4513298 0.76 ALDH1A1 (0.81) ALDH1A1CYP1A2CYP2C9CYP2C19POLB
SCHEMBL4515726 0.76 ALDH1A1 (0.81) ALDH1A1CYP1A2CYP2C9CYP2C19POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0543861-A1 IMIDAZOPYRIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION BRITISH BIO-TECHNOLOGY LIMITED (GB) 1993-06-02 EP claimed
WO-1992003422-A1 BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION BRITISH BIO-TECHNOLOGY LIMITED (GB) 1992-03-05 WO claimed
EP-0543861-A1 IMIDAZOPYRIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION BRITISH BIO-TECHNOLOGY LIMITED (GB) 1993-06-02 EP disclosed
US-5180723-A Hypertensives, bronchodilators, antiedemic agents BRITISH BIO-TECHNOLOGY LIMITED (GB) 1993-01-19 US disclosed
WO-1992003422-A1 BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION BRITISH BIO-TECHNOLOGY LIMITED (GB) 1992-03-05 WO disclosed