SCHEMBL950222

SCHEMBL950222

Clc1cccnc1-n1cnc(Br)c1

nearest known ligand 0.42

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
RPS6KA5 O75582 2/20 0.35
HSD11B1 P28845 1/20 0.34
TRPA1 O75762 2/20 0.33
MALT1 Q9UDY8 1/20 0.33
TRPV1 Q8NER1 2/20 0.32
KDM4E B2RXH2 1/20 0.32
BRD4 O60885 1/20 0.32
LMNA P02545 1/20 0.32
HSP90AA1 P07900 1/20 0.32
MAPT P10636 1/20 0.32
METAP2 P50579 1/20 0.32
METAP1 P53582 1/20 0.32
RPS6KA4 O75676 1/20 0.31
CYP17A1 P05093 1/20 0.31
CYP1A2 P05177 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12528879 0.75 PHF8 (0.48) KDM4ELMNAMAPT
SCHEMBL951374 0.74 HTR3E (0.40) RPS6KA5HSD11B1TRPA1MALT1TRPV1
SCHEMBL535711 0.70 HSD11B1 (0.35) RPS6KA5HSD11B1TRPA1MALT1TRPV1
SCHEMBL535417 0.70 TRPA1 (0.34) RPS6KA5HSD11B1TRPA1MALT1TRPV1
SCHEMBL536183 0.70 TRPA1 (0.34) RPS6KA5HSD11B1TRPA1MALT1TRPV1
SCHEMBL30337851 0.69 SMN1; SMN2 (0.43)
SCHEMBL6172976 0.69 SMN1; SMN2 (0.43)
SCHEMBL27793748 0.69 RPS6KA5 (0.35) RPS6KA5HSD11B1TRPA1MALT1TRPV1
SCHEMBL435321 0.69 RPS6KA5 (0.35) RPS6KA5HSD11B1TRPA1MALT1TRPV1
SCHEMBL23248718 0.68 RPS6KA5 (0.35) RPS6KA5HSD11B1TRPA1MALT1TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101287721-B Hydrazide compound and pesticidal use of the same SUMITOMO CO LTD 2013-03-27 CN disclosed
US-7968573-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-06-28 US disclosed
EP-1937664-B1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2011-06-15 EP disclosed
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME IKEGAMI HIROSHI 2011-03-24 US disclosed
US-7867949-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-11 US disclosed
EP-2251336-A1 Hydrazide compounds as intermediates of pesticides Sumitomo Chemical Company, Limited (JP) 2010-11-17 EP disclosed
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-16 US disclosed
CN-101287721-A Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL CO (JP) 2008-10-15 CN disclosed
WO-2007043677-A9 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2007-06-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME ACHE, H1-2, H1-0 RPS6KA5 2425/4885HSD11B1 1797/4885TRPA1 437/4885
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same ACHE, DDT, CAT RPS6KA5 3415/4885HSD11B1 651/4885TRPA1 359/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.