Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.55 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 2/20 | 0.55 |
| ▸ | SLC6A9 | P48067 | 7/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL9502668 | 1.00 | SLC6A4 (0.55) | SLC6A4HRH3SLC6A9 | |
| Maleic Acid SCHEMBL7319208 | 0.87 | SLC6A9 (0.64) | SLC6A4HRH3SLC6A9 | |
| Fumaric Acid SCHEMBL7319213 | 0.87 | SLC6A9 (0.64) | SLC6A4HRH3SLC6A9 | |
| Fumaric Acid SCHEMBL7311088 | 0.86 | SLC6A9 (0.60) | SLC6A4HRH3SLC6A9 | |
| Maleic Acid SCHEMBL7311084 | 0.86 | SLC6A9 (0.60) | SLC6A4HRH3SLC6A9 | |
| Fumaric Acid SCHEMBL7315531 | 0.80 | SLC6A9 (0.64) | SLC6A4HRH3SLC6A9 | |
| Maleic Acid SCHEMBL7315527 | 0.80 | SLC6A9 (0.64) | SLC6A4HRH3SLC6A9 | |
| SCHEMBL7158810 | 0.78 | SLC6A4 (0.73) | SLC6A4HRH3SLC6A9 | |
| Oxalic Acid SCHEMBL5142654 | 0.78 | SLC6A9 (0.68) | SLC6A4HRH3SLC6A9 | |
| SCHEMBL9500943 | 0.77 | SLC6A4 (0.68) | SLC6A4HRH3SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5238959-A | For inhibiting serotonin uptake, antidepressant, suppression of alcoholism and obesity | ELI LILLY AND COMPANY (US) | 1993-08-24 | — | — | US | disclosed |
| EP-0336753-B1 | IMPROVEMENTS IN OR RELATING TO PROPANAMINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1992-07-08 | — | — | EP | disclosed |
| EP-0336753-A1 | Improvements in or relating to propanamine derivatives | ELI LILLY AND COMPANY (US) | 1989-10-11 | — | — | EP | disclosed |