Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.46 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8845543 | 0.83 | PLA2G4A (0.44) | MTNR1AMTNR1BMAOAMAOBKDM4C | |
| SCHEMBL8845775 | 0.82 | PLG (0.45) | CYP17A1HRH1KDM4CCYP24A1HDAC6 | |
| SCHEMBL18856948 | 0.79 | MTNR1A (0.58) | SLC6A2HTR2CMTNR1AMTNR1BHTR2A | |
| SCHEMBL9502783 | 0.79 | ITGB3 (0.48) | HTR2CMTNR1AMTNR1BSMPD1HTR2A | |
| SCHEMBL8845721 | 0.78 | MAOA (0.44) | SMPD1MAOAMAOBKDM4C | |
| SCHEMBL4394621 | 0.78 | MTNR1A (0.56) | SLC6A2HTR2CMTNR1AMTNR1BHTR2A | |
| SCHEMBL5841872 | 0.78 | HTR2C (0.55) | HTR2CMTNR1AMTNR1BHTR2AHDAC3 | |
| SCHEMBL10413240 | 0.78 | MTNR1A (0.59) | SLC6A2HTR2CMTNR1AMTNR1BSMPD1 | |
| SCHEMBL21245824 | 0.77 | HTR2C (0.57) | HTR2CMTNR1AMTNR1BHTR2AHDAC3 | |
| SCHEMBL5988329 | 0.77 | HTR2C (0.57) | HTR2CMTNR1AMTNR1BHTR2AHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5214058-A | Acetylcholinesterase inhibitors, treatment of senile dementia | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-05-25 | — | — | US | claimed |
| US-5214058-A | Acetylcholinesterase inhibitors, treatment of senile dementia | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-05-25 | — | — | US | disclosed |
| EP-0471296-A1 | 1-(Pyridinylalkyl)-1H-indoles, indolines and related analogs | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-02-19 | — | — | EP | disclosed |