Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | LTA4H | P09960 | 4/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9503534 | 0.95 | MAOA (0.50) | MAOAMAOBLTA4HALDH1A1KDM4E | |
| SCHEMBL9503139 | 0.89 | MAOA (0.47) | MAOAMAOBLTA4HALDH1A1KDM4E | |
| SCHEMBL9501765 | 0.82 | SLC6A4 (0.44) | MAOAMAOBLTA4HALDH1A1NPC1 | |
| SCHEMBL9503489 | 0.81 | LTA4H (0.43) | MAOAMAOBLTA4HALDH1A1KDM4E | |
| SCHEMBL9503541 | 0.80 | LTA4H (0.66) | LTA4HNPC1RAB9ATSHRTP53 | |
| SCHEMBL9503567 | 0.80 | LTA4H (0.63) | LTA4HALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL9705598 | 0.79 | HDAC3 (0.42) | MAOAMAOBTHRATHRBALDH1A1 | |
| SCHEMBL9502761 | 0.78 | THRB (0.49) | LTA4HTHRATHRBALDH1A1KDM4E | |
| SCHEMBL5824030 | 0.77 | MAPT (0.46) | THRATHRBALDH1A1KDM4ELMNA | |
| SCHEMBL17608773 | 0.77 | KDM4E (0.49) | MAOAMAOBLTA4HALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0186190-B1 | BENZIMIDAZOLE DERIVATIVES, AND THEIR PRODUCTION AND USE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1993-05-26 | — | — | EP | disclosed |
| EP-0132606-B1 | BENZIMIDAZOLE DERIVATIVES, AND THEIR PRODUCTION AND USE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1987-10-07 | — | — | EP | disclosed |
| US-4663339-A | Acaricidal and insecticidal substituted 1-phenylalkylbenzimidazoles | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1987-05-05 | — | — | US | disclosed |
| US-4612323-A | Insecticidal and acaricidal derivatives of 1-benzylbenzimidazole | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1986-09-16 | — | — | US | disclosed |
| EP-0186190-A2 | Benzimidazole derivatives, and their production and use | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1986-07-02 | — | — | EP | disclosed |